| pubmed-article:12061549 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C0521057 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C0038420 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C1449702 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:12061549 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:12061549 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12061549 | pubmed:dateCreated | 2002-6-13 | lld:pubmed |
| pubmed-article:12061549 | pubmed:abstractText | We have identified a strain of Streptomyces in which aerial hyphae formation appears to be especially sensitive to inhibition by protein kinase inhibitors. Using this assay, a number of bacterial cultures have been screened and novel inhibitors of eukaryotic protein kinases have been identified. Since M. tuberculosis possesses multiple eukaryotic-like protein kinase genes, we tested the active kinase inhibitors for the inhibition of mycobacterial growth and obtained several potent compounds. This identifies a new biochemical class of antimycobacterial agents. | lld:pubmed |
| pubmed-article:12061549 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12061549 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12061549 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12061549 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12061549 | pubmed:issn | 0021-8820 | lld:pubmed |
| pubmed-article:12061549 | pubmed:author | pubmed-author:WangguiYangsh... | lld:pubmed |
| pubmed-article:12061549 | pubmed:author | pubmed-author:DaviesJulianJ | lld:pubmed |
| pubmed-article:12061549 | pubmed:author | pubmed-author:WatersBarbara... | lld:pubmed |
| pubmed-article:12061549 | pubmed:author | pubmed-author:SaxenaGeetaG | lld:pubmed |
| pubmed-article:12061549 | pubmed:author | pubmed-author:KauDavidD | lld:pubmed |
| pubmed-article:12061549 | pubmed:author | pubmed-author:WrigleyStephe... | lld:pubmed |
| pubmed-article:12061549 | pubmed:author | pubmed-author:StokesRichard... | lld:pubmed |
| pubmed-article:12061549 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12061549 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:12061549 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12061549 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12061549 | pubmed:pagination | 407-16 | lld:pubmed |
| pubmed-article:12061549 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:meshHeading | pubmed-meshheading:12061549... | lld:pubmed |
| pubmed-article:12061549 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12061549 | pubmed:articleTitle | Identifying protein kinase inhibitors using an assay based on inhibition of aerial hyphae formation in Streptomyces. | lld:pubmed |
| pubmed-article:12061549 | pubmed:affiliation | Cubist Pharmaceuticals, Inc., Vancouver, BC, Canada. | lld:pubmed |
| pubmed-article:12061549 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12061549 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
