| pubmed-article:12060667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0374711 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0348801 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0009207 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C1705181 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0050084 | lld:lifeskim |
| pubmed-article:12060667 | lifeskim:mentions | umls-concept:C0441836 | lld:lifeskim |
| pubmed-article:12060667 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:12060667 | pubmed:dateCreated | 2002-8-19 | lld:pubmed |
| pubmed-article:12060667 | pubmed:abstractText | Cockayne syndrome (CS) is a human disease characterized by sensitivity to sunlight, severe neurological abnormalities, and accelerated aging. CS has two complementation groups, CS-A and CS-B. The CSB gene encodes the CSB protein with 1493 amino acids. We previously reported that the CSB protein is involved in cellular repair of 8-hydroxyguanine, an abundant lesion in oxidatively damaged DNA and that the putative helicase motif V/VI of the CSB may play a role in this process. The present study investigated the role of the CSB protein in cellular repair of 8-hydroxyadenine (8-OH-Ade), another abundant lesion in oxidatively damaged DNA. Extracts of CS-B-null cells and mutant cells with site-directed mutation in the motif VI of the putative helicase domain incised 8-hydroxyadenine in vitro less efficiently than wild type cells. Furthermore, CS-B-null and motif VI mutant cells accumulated more 8-hydroxyadenine in their genomic DNA than wild type cells after exposure to gamma-radiation at doses of 2 or 5 Gy. These results suggest that the CSB protein contributes to cellular repair of 8-OH-Ade and that the motif VI of the putative helicase domain of CSB is required for this activity. | lld:pubmed |
| pubmed-article:12060667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12060667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12060667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12060667 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12060667 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12060667 | pubmed:author | pubmed-author:JarugaPawelP | lld:pubmed |
| pubmed-article:12060667 | pubmed:author | pubmed-author:DizdarogluMir... | lld:pubmed |
| pubmed-article:12060667 | pubmed:author | pubmed-author:TuoJingshengJ | lld:pubmed |
| pubmed-article:12060667 | pubmed:author | pubmed-author:BohrVilhelm... | lld:pubmed |
| pubmed-article:12060667 | pubmed:author | pubmed-author:RodriguezHenr... | lld:pubmed |
| pubmed-article:12060667 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12060667 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:12060667 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:12060667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12060667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12060667 | pubmed:pagination | 30832-7 | lld:pubmed |
| pubmed-article:12060667 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12060667 | pubmed:meshHeading | pubmed-meshheading:12060667... | lld:pubmed |
| pubmed-article:12060667 | pubmed:meshHeading | pubmed-meshheading:12060667... | lld:pubmed |
| pubmed-article:12060667 | pubmed:meshHeading | pubmed-meshheading:12060667... | lld:pubmed |
| pubmed-article:12060667 | pubmed:meshHeading | pubmed-meshheading:12060667... | lld:pubmed |
| pubmed-article:12060667 | pubmed:meshHeading | pubmed-meshheading:12060667... | lld:pubmed |
| pubmed-article:12060667 | pubmed:meshHeading | pubmed-meshheading:12060667... | lld:pubmed |
| pubmed-article:12060667 | pubmed:meshHeading | pubmed-meshheading:12060667... | lld:pubmed |
| pubmed-article:12060667 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12060667 | pubmed:articleTitle | The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA. | lld:pubmed |
| pubmed-article:12060667 | pubmed:affiliation | Laboratory of Molecular Gerontology, National Institute on Aging/NIH, Baltimore, MD 21224, USA. | lld:pubmed |
| pubmed-article:12060667 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12060667 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:2074 | entrezgene:pubmed | pubmed-article:12060667 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12060667 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12060667 | lld:pubmed |
