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pubmed-article:12057665pubmed:abstractTextThe proposed phenyl-A region of sigma (sigma) receptors accommodates several structural features. In this study we explored the possibility that appropriate structural features located at the phenyl-A region of sigma receptor sites could lead to more potent and selective agents for the sigma receptor subtypes. By keeping the phenyl-B substituent as the optimum omega-phenylpentyl moiety, and varying substituents in the phenyl-A region, we have observed changes in binding potency and selectivity at the sigma receptor subtypes. SAR for the binding of these compounds at sigma-2 sites was also examined.lld:pubmed
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pubmed-article:12057665pubmed:pagination2759-65lld:pubmed
pubmed-article:12057665pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:12057665pubmed:year2002lld:pubmed
pubmed-article:12057665pubmed:articleTitleProbing the proposed phenyl-A region of the sigma-1 receptor.lld:pubmed
pubmed-article:12057665pubmed:affiliationCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA. seth.ablordeppey@famu.edulld:pubmed
pubmed-article:12057665pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12057665pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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