| pubmed-article:12054798 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12054798 | lifeskim:mentions | umls-concept:C0290149 | lld:lifeskim |
| pubmed-article:12054798 | lifeskim:mentions | umls-concept:C0596087 | lld:lifeskim |
| pubmed-article:12054798 | lifeskim:mentions | umls-concept:C0043309 | lld:lifeskim |
| pubmed-article:12054798 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12054798 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12054798 | pubmed:dateCreated | 2002-6-10 | lld:pubmed |
| pubmed-article:12054798 | pubmed:abstractText | Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-shaped structure of angiostatin kringles 1-3, the first multi-kringle structure to be determined. All three kringle lysine-binding sites contain a bound bicine molecule of crystallization while the former of kringle 2 and kringle 3 are cofacial. Moreover, the separation of the kringle 2 and kringle 3 lysiner binding sites is sufficient to accommodate the alpha-helix of the 30 residue peptide VEK-30 found in the kringle 2/VEK-30 complex. Together the three kringles produce a central cavity suggestive of a unique domain where they may function in concert. | lld:pubmed |
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| pubmed-article:12054798 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12054798 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12054798 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12054798 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12054798 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12054798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12054798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12054798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12054798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12054798 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12054798 | pubmed:month | May | lld:pubmed |
| pubmed-article:12054798 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:12054798 | pubmed:author | pubmed-author:BrayE WEW3rd | lld:pubmed |
| pubmed-article:12054798 | pubmed:author | pubmed-author:GeigerJames... | lld:pubmed |
| pubmed-article:12054798 | pubmed:author | pubmed-author:AbadMarta CMC | lld:pubmed |
| pubmed-article:12054798 | pubmed:author | pubmed-author:CastellinoFra... | lld:pubmed |
| pubmed-article:12054798 | pubmed:author | pubmed-author:GrellaDavida... | lld:pubmed |
| pubmed-article:12054798 | pubmed:author | pubmed-author:TulinskyAlexa... | lld:pubmed |
| pubmed-article:12054798 | pubmed:copyrightInfo | (c) 2002 Elsevier Science Ltd. | lld:pubmed |
| pubmed-article:12054798 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12054798 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:12054798 | pubmed:volume | 318 | lld:pubmed |
| pubmed-article:12054798 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12054798 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12054798 | pubmed:pagination | 1009-17 | lld:pubmed |
| pubmed-article:12054798 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12054798 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12054798 | pubmed:articleTitle | The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. | lld:pubmed |
| pubmed-article:12054798 | pubmed:affiliation | Department of Chemistry, Michigan State University, East Lansing 48824, USA. | lld:pubmed |
| pubmed-article:12054798 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12054798 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12054798 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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