| pubmed-article:12052884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C0032112 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:12052884 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12052884 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:12052884 | pubmed:dateCreated | 2002-6-7 | lld:pubmed |
| pubmed-article:12052884 | pubmed:abstractText | B-cell lineage-specific activator protein (BSAP), encoded by the Pax-5 gene, is critical for B-cell lineage commitment and B-cell development but is not expressed in terminally differentiated B cells. We demonstrate a direct connection between BSAP and B-lymphocyte-induced maturation protein 1 (Blimp-1), a transcriptional repressor that is sufficient to drive plasmacytic differentiation. Blimp-1 binds a site on the Pax-5 promoter in vitro and in vivo and represses the Pax-5 promoter in a binding-site-dependent manner. By ectopically expressing Blimp-1 or a competitive inhibitor of Blimp-1, we show that Blimp-1 is both necessary and sufficient to repress Pax-5 during plasmacytic differentiation of primary splenic B cells. Blimp-1-dependent repression of Pax-5 is sufficient to regulate BSAP targets CD19 and J chain and is necessary but not sufficient to induce XBP-1. We further show that repression of Pax-5 is required for Blimp-1 to drive differentiation of splenocytes to immunoglobulin M-secreting cells. Thus, repression of Pax-5 plays a critical role in the Blimp-1-dependent program of plasmacytic differentiation. | lld:pubmed |
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| pubmed-article:12052884 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12052884 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12052884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12052884 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12052884 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:12052884 | pubmed:author | pubmed-author:KumarM WMW | lld:pubmed |
| pubmed-article:12052884 | pubmed:author | pubmed-author:Angelin-Duclo... | lld:pubmed |
| pubmed-article:12052884 | pubmed:author | pubmed-author:KuoTracy CTC | lld:pubmed |
| pubmed-article:12052884 | pubmed:author | pubmed-author:CalameKathryn... | lld:pubmed |
| pubmed-article:12052884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12052884 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12052884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12052884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12052884 | pubmed:pagination | 4771-80 | lld:pubmed |
| pubmed-article:12052884 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12052884 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12052884 | pubmed:articleTitle | Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. | lld:pubmed |
| pubmed-article:12052884 | pubmed:affiliation | Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:12052884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12052884 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12052884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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