| pubmed-article:12052882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C0076930 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:12052882 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12052882 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:12052882 | pubmed:dateCreated | 2002-6-7 | lld:pubmed |
| pubmed-article:12052882 | pubmed:abstractText | Members of the transforming growth factor beta (TGF-beta) family of proteins signal through cell surface transmembrane serine/threonine protein kinases known as type I and type II receptors. The TGF-beta signal is extended through phosphorylation of receptor-associated Smad proteins by the type I receptor. Although numerous investigations have established the sequence of events in TGF-beta receptor (TGF-beta R) activation, none have examined the role of the endocytic pathway in initiation and/or maintenance of the signaling response. In this study we investigated whether TGF-beta R internalization modulates type I receptor activation, the formation of a functional receptor/Smad/SARA complex, Smad2/3 phosphorylation or nuclear translocation, and TGF-beta-dependent reporter gene activity. Our data provide evidence that, whereas type I receptor phosphorylation and association of SARA and Smad2 with the TGF-beta R complex take place independently of clathrin lattice formation, Smad2 or Smad3 activation and downstream signaling only occur after endocytic vesicle formation. Thus, TGF-beta R endocytosis is not simply a way to dampen the signaling response but instead is required to propagate signaling via the Smad pathway. | lld:pubmed |
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| pubmed-article:12052882 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12052882 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12052882 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12052882 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12052882 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12052882 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:12052882 | pubmed:author | pubmed-author:PenheiterSume... | lld:pubmed |
| pubmed-article:12052882 | pubmed:author | pubmed-author:MitchellHughH | lld:pubmed |
| pubmed-article:12052882 | pubmed:author | pubmed-author:GaramszegiNan... | lld:pubmed |
| pubmed-article:12052882 | pubmed:author | pubmed-author:EdensMaryanne... | lld:pubmed |
| pubmed-article:12052882 | pubmed:author | pubmed-author:DoréJules J... | lld:pubmed |
| pubmed-article:12052882 | pubmed:author | pubmed-author:LeofEdward... | lld:pubmed |
| pubmed-article:12052882 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12052882 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12052882 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12052882 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12052882 | pubmed:pagination | 4750-9 | lld:pubmed |
| pubmed-article:12052882 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12052882 | pubmed:meshHeading | pubmed-meshheading:12052882... | lld:pubmed |
| pubmed-article:12052882 | pubmed:meshHeading | pubmed-meshheading:12052882... | lld:pubmed |
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| pubmed-article:12052882 | pubmed:meshHeading | pubmed-meshheading:12052882... | lld:pubmed |
| pubmed-article:12052882 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12052882 | pubmed:articleTitle | Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway. | lld:pubmed |
