| pubmed-article:12048245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C1708800 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C1367675 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C1150582 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:12048245 | lifeskim:mentions | umls-concept:C0060001 | lld:lifeskim |
| pubmed-article:12048245 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12048245 | pubmed:dateCreated | 2002-6-12 | lld:pubmed |
| pubmed-article:12048245 | pubmed:abstractText | IFN-gamma induces a number of genes to up-regulate cellular responses by using specific transcription factors and the cognate elements. We recently discovered that CCAAT/enhancer-binding protein-beta (C/EBP-beta) induces gene transcription through an IFN-response element called gamma-IFN-activated transcriptional element (GATE). Using mutant cells, chemical inhibitors, and specific dominant negative inhibitors, we show that induction of GATE-driven gene expression depends on MEK1 (mitogen-activated protein kinase kinase/extracellular signal-regulated protein kinase kinase) and ERKs (extracellular signal-regulated protein kinases) but is independent of Raf-1. Interestingly in cells lacking the MEKK1 gene or expressing the dominant negative MEKK1, ERK activation, and GATE dependent gene expression is inhibited. A dominant negative MEKK1 blocks C/EBP-beta-driven gene expression stimulated by IFN-gamma. These studies describe an IFN-gamma-stimulated pathway that involves MEKK1-MEK1-ERK1/2 kinases to regulate C/EBP-beta-dependent gene expression. | lld:pubmed |
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| pubmed-article:12048245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12048245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12048245 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12048245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12048245 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12048245 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:ThumbooJJ | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:ReddySekhar... | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:JohnsonPeter... | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:PlataniasLeon... | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:KalvakolanuDh... | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:PritchardCatr... | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:XiaYingY | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:LindnerDaniel... | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:HuJunboJ | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:RoySanjit KSK | lld:pubmed |
| pubmed-article:12048245 | pubmed:author | pubmed-author:MengQingjunQ | lld:pubmed |
