| pubmed-article:12046988 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0271650 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0081937 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0243102 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12046988 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:12046988 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12046988 | pubmed:dateCreated | 2002-6-5 | lld:pubmed |
| pubmed-article:12046988 | pubmed:abstractText | This study was performed to determine the effects of a high-fat diet on glucose metabolism after an oral glucose challenge in high-fat diet-fed dipeptidyl peptidase IV (DPP-IV) positive (+) and deficient (-) Fischer 344 (F344) rats and the effects of novel DPP-IV inhibitor NVP-DPP728 (1-[2-[(5-cyanopyridin-2-yl)amino]ethylamino]acetyl-2-cyano-(S)-pyrrolidine monohydrochloride salt) on glucose tolerance in high-fat diet-fed F344 rats. In DPP-IV(+) rats, a high-fat diet load caused impaired glucose tolerance, such as increases of plasma insulin and blood glucose concentrations after oral glucose challenge, compared with a standard chow-fed group. In contrast, no marked change in glucose tolerance was induced by the high-fat diet in DPP-IV(-) rats. Blood glucose concentrations in DPP-IV(-) rats after glucose challenge were significantly lower than in DPP-IV(+) rats under high-fat diet load conditions. In standard chow and high-fat diet-fed DPP-IV(+) rats, NVP-DPP728 significantly suppressed glucose excursions after glucose challenge by inhibiting the plasma DPP-IV activity, associated with the stimulation of early insulin secretion. NVP-DPP728 did not affect glucose tolerance in DPP-IV(-) rats under both conditions. These results indicate that the amelioration of glucose tolerance by NVP-DPP728 in DPP-IV(+) rats was directly due to the inhibition of plasma DPP-IV activity, which might be via the subsequent increase in endogenous incretin action. | lld:pubmed |
| pubmed-article:12046988 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12046988 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12046988 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12046988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12046988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12046988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12046988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12046988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12046988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12046988 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12046988 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12046988 | pubmed:issn | 0021-5198 | lld:pubmed |
| pubmed-article:12046988 | pubmed:author | pubmed-author:HughesThomas... | lld:pubmed |
| pubmed-article:12046988 | pubmed:author | pubmed-author:MitaniHironob... | lld:pubmed |
| pubmed-article:12046988 | pubmed:author | pubmed-author:TakimotoMisat... | lld:pubmed |
| pubmed-article:12046988 | pubmed:author | pubmed-author:KimuraMasaaki... | lld:pubmed |
| pubmed-article:12046988 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12046988 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:12046988 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12046988 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12046988 | pubmed:pagination | 442-50 | lld:pubmed |
| pubmed-article:12046988 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:12046988 | pubmed:meshHeading | pubmed-meshheading:12046988... | lld:pubmed |
| pubmed-article:12046988 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12046988 | pubmed:articleTitle | Dipeptidyl peptidase IV inhibition improves impaired glucose tolerance in high-fat diet-fed rats: study using a Fischer 344 rat substrain deficient in its enzyme activity. | lld:pubmed |
| pubmed-article:12046988 | pubmed:affiliation | Research Division, Tsukuba Research Institute, Novartis Pharma K.K., Japan. hironobu.mitani@pharma.novartis.com | lld:pubmed |
| pubmed-article:12046988 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12046988 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12046988 | lld:pubmed |
