| pubmed-article:12045261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C0332835 | lld:lifeskim |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:12045261 | lifeskim:mentions | umls-concept:C0456389 | lld:lifeskim |
| pubmed-article:12045261 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12045261 | pubmed:dateCreated | 2002-6-4 | lld:pubmed |
| pubmed-article:12045261 | pubmed:abstractText | The Th1 cytokines IL-2 and IFN-gamma, which inhibit T cell proliferation and promote activation induced cell death, may be required to diminish alloreactive T cell numbers and to foster tolerance across full allogeneic barriers. However, we hypothesized that these cytokines might be dispensable when the alloreactive T cell clone size is relatively small, as is seen in recipients of minor-mismatched grafts. We show that alloreactive T cell clone size of C57BL/6 mice against multiple minor-mismatched 129X1/sv mice was approximately 4-9-fold smaller than that against MHC-mismatched BALB/c mice. In the MHC-mismatched combination, CD28-B7 blockade by CTLA4Ig induced long-term graft survival in wild-type recipients, but this treatment was ineffective in IFNgamma(-/-) or IL-2(-/-) recipients. In contrast, in the minor-mismatched combination, CTLA4Ig induced long-term allograft survival in wild-type, IFNgamma(-/-), and IL-2(-/-) recipients. Bcl-x(L) transgenic animals, which are defective in "passive" T cell death, are likewise sensitive to the effects of CTLA4Ig only in the setting of the minor-mismatch grafts. Therefore, the alloreactive T cell clone size is an important determinant affecting the need for Th1 cytokines and T cell death in tolerance induction. These data have implications for the design of tolerance strategies in transplant recipients with varying degrees of MHC mismatching. | lld:pubmed |
| pubmed-article:12045261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12045261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12045261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12045261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12045261 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12045261 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:SayeghMohamed... | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:StromTerry... | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:TurkaLaurence... | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:KishimotoKoji... | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:RothsteinDavi... | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:ImitolaJaimeJ | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:SandnerSigrid... | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:ShoMasayukiM | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:LiYongshengY | lld:pubmed |
| pubmed-article:12045261 | pubmed:author | pubmed-author:LangmuirPeter... | lld:pubmed |
| pubmed-article:12045261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12045261 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:12045261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12045261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12045261 | pubmed:pagination | 1471-9 | lld:pubmed |
| pubmed-article:12045261 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
| pubmed-article:12045261 | pubmed:meshHeading | pubmed-meshheading:12045261... | lld:pubmed |
