| pubmed-article:12042777 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12042777 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:12042777 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:12042777 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12042777 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12042777 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12042777 | pubmed:dateCreated | 2002-7-1 | lld:pubmed |
| pubmed-article:12042777 | pubmed:abstractText | RNA interference silences gene expression through short interfering 21 23-mer double-strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here we report that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein. siRNAs effectively inhibit pre- and/or post-integration infection events in the HIV-1 life cycle. Thus, siRNAs may have potential for therapeutic intervention in HIV-1 and other viral infections. | lld:pubmed |
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| pubmed-article:12042777 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12042777 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12042777 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12042777 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12042777 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:SharpPhillip... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:BeresfordPaul... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:LiebermanJudy... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:ShankarPremla... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:NovinaCarl... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:MurrayMichael... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:DykxhoornDere... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:RiessJonathan... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:LeeSang-Kyung... | lld:pubmed |
| pubmed-article:12042777 | pubmed:author | pubmed-author:CollmanRonald... | lld:pubmed |
| pubmed-article:12042777 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12042777 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:12042777 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12042777 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12042777 | pubmed:pagination | 681-6 | lld:pubmed |
| pubmed-article:12042777 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12042777 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12042777 | pubmed:articleTitle | siRNA-directed inhibition of HIV-1 infection. | lld:pubmed |
| pubmed-article:12042777 | pubmed:affiliation | Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. | lld:pubmed |
| pubmed-article:12042777 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12042777 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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