Linked Life Data

12040039

Source:http://linkedlifedata.com/resource/pubmed/id/12040039

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12040039rdf:typepubmed:Citationlld:pubmed
pubmed-article:12040039lifeskim:mentionsumls-concept:C0038435lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C0162508lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C0682702lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C0033640lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C0441655lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C1367731lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C1150587lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C1705632lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C0086597lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:12040039lifeskim:mentionsumls-concept:C0150312lld:lifeskim
pubmed-article:12040039pubmed:issue11lld:pubmed
pubmed-article:12040039pubmed:dateCreated2002-5-31lld:pubmed
pubmed-article:12040039pubmed:abstractTextc-Jun is considered a major regulator of both neuronal death and regeneration. Stress in primary cultured CNS neurons induces phosphorylation of c-Jun serines 63 and 73 and increased c-Jun protein. However, total c-Jun N-terminal protein kinase (JNK) activity does not increase, and no satisfactory explanation for this paradox has been available. Here we demonstrate that neuronal stress induces strong activation of JNK2/3 in the presence of constitutively and highly active JNK1. Correspondingly, neurons from JNK1(-/-) mice show lower constitutive activity and considerably higher responsiveness to stress. p38 activity can be completely inhibited without effect on c-Jun phosphorylation, whereas 10 micrometer SB203580 strongly inhibits neuronal JNK2/3, stress-induced c-Jun phosphorylation, induced c-Jun activity, and neuronal death in response to trophic withdrawal stress. Neither constitutive JNK1 activity nor total neuronal JNK activity were significantly affected by this concentration of drug. Thus, neuronal stress selectively activates JNK2/3 in the presence of mechanisms maintaining constitutive JNK1 activity, and this JNK2/3 activity selectively targets c-Jun, which is isolated from constitutive JNK1 activity.lld:pubmed
pubmed-article:12040039pubmed:languageenglld:pubmed
pubmed-article:12040039pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:citationSubsetIMlld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12040039pubmed:statusMEDLINElld:pubmed
pubmed-article:12040039pubmed:monthJunlld:pubmed
pubmed-article:12040039pubmed:issn1529-2401lld:pubmed
pubmed-article:12040039pubmed:authorpubmed-author:CourtneyMicha...lld:pubmed
pubmed-article:12040039pubmed:authorpubmed-author:CoffeyEleanor...lld:pubmed
pubmed-article:12040039pubmed:authorpubmed-author:SmicieneGiedr...lld:pubmed
pubmed-article:12040039pubmed:authorpubmed-author:HongistoVesaVlld:pubmed
pubmed-article:12040039pubmed:authorpubmed-author:CaoJiongJlld:pubmed
pubmed-article:12040039pubmed:authorpubmed-author:BrechtStephan...lld:pubmed
pubmed-article:12040039pubmed:authorpubmed-author:HerdegenThoma...lld:pubmed
pubmed-article:12040039pubmed:issnTypeElectroniclld:pubmed
pubmed-article:12040039pubmed:day1lld:pubmed
pubmed-article:12040039pubmed:volume22lld:pubmed
pubmed-article:12040039pubmed:ownerNLMlld:pubmed
pubmed-article:12040039pubmed:authorsCompleteYlld:pubmed
pubmed-article:12040039pubmed:pagination4335-45lld:pubmed
pubmed-article:12040039pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:meshHeadingpubmed-meshheading:12040039...lld:pubmed
pubmed-article:12040039pubmed:year2002lld:pubmed
pubmed-article:12040039pubmed:articleTitlec-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.lld:pubmed
pubmed-article:12040039pubmed:affiliationDepartment of Biochemistry and Pharmacy Abo Akademi University, Biocity, Turku, FIN 20521, Finland.lld:pubmed
pubmed-article:12040039pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12040039pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12040039lld:pubmed
More...