| pubmed-article:12039587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C2267054 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C1148561 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C1551022 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C2698650 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12039587 | lifeskim:mentions | umls-concept:C1961136 | lld:lifeskim |
| pubmed-article:12039587 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12039587 | pubmed:dateCreated | 2002-5-31 | lld:pubmed |
| pubmed-article:12039587 | pubmed:abstractText | Further optimization of the beta-aminoester class of factor Xa (fXa) inhibitors is described culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with excellent in vivo anticoagulant activity. An X-ray structure of FXV673 bound to human fXa is also presented. Based on its selectivity, potent in vivo activity and favorable pre-clinical safety profile, FXV673 was selected for further development and is currently undergoing clinical trials. | lld:pubmed |
| pubmed-article:12039587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12039587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12039587 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12039587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12039587 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12039587 | pubmed:issn | 0960-894X | lld:pubmed |
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| pubmed-article:12039587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12039587 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:12039587 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12039587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12039587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12039587 | pubmed:pagination | 1671-4 | lld:pubmed |
| pubmed-article:12039587 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:12039587 | pubmed:meshHeading | pubmed-meshheading:12039587... | lld:pubmed |
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| pubmed-article:12039587 | pubmed:meshHeading | pubmed-meshheading:12039587... | lld:pubmed |
| pubmed-article:12039587 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12039587 | pubmed:articleTitle | Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity. | lld:pubmed |
| pubmed-article:12039587 | pubmed:affiliation | Drug Innovation and Approval, Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA. kevin.guertin@roche.com | lld:pubmed |
| pubmed-article:12039587 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12039587 | lld:chembl |
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