| pubmed-article:12039075 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12039075 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:12039075 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:12039075 | lifeskim:mentions | umls-concept:C0033572 | lld:lifeskim |
| pubmed-article:12039075 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12039075 | lifeskim:mentions | umls-concept:C1171892 | lld:lifeskim |
| pubmed-article:12039075 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12039075 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:12039075 | pubmed:dateCreated | 2002-5-31 | lld:pubmed |
| pubmed-article:12039075 | pubmed:abstractText | In cloning tyrosine kinase genes in dog prostate cells, a fragment of the vascular endothelial growth factor (VEGF) receptor 1 or Flt-1 was sequenced. To test for a functional protein, Flt-1 antibodies were used to probe immunoprecipitated tyrosine phosphorylated proteins. Western blotting revealed a major 170-180 kDa band and a few bands below 116 kDa in dog prostate and human prostatic carcinoma PC-3 cells, with higher levels in PC-3. Similar results were obtained with human placental membranes used as a source of Flt-1. That the major Flt-1 tyrosine phosphorylated protein was likely VEGF-R1 and part of VEGF signaling pathways was shown by enhanced level of only this protein when PC-3 cells were exposed to VEGF. Accordingly specific cell surface receptor complexes, displaced by VEGF but not EGF and compatible with Flt-1 in size, were revealed by chemical cross-linking after 125I-VEGF binding. Similarly to the prostatic neuroproduct, gastrin-releasing peptide/bombesin, VEGF directly triggered the tyrosine phosphorylation of focal adhesion kinase and stimulated PC-3 cell motility. The titration of prostate tissue sections with VEGF-A antibodies revealed a confined staining in chromogranin A and/or serotonin positive neuroendocrine (NE) cells, including in primary tumors and lymph node metastases. Given that NE differentiation is associated with advanced disease, that NE cells are a significant source of VEGF in prostatic tumors, and that VEGF directly act on prostate cancer cells in vitro, VEGF-A may be more than angiogenic in prostate cancer and hence favor progression by affecting tumor cells. | lld:pubmed |
| pubmed-article:12039075 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12039075 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12039075 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12039075 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12039075 | pubmed:issn | 0303-7207 | lld:pubmed |
| pubmed-article:12039075 | pubmed:author | pubmed-author:LacosteJJ | lld:pubmed |
| pubmed-article:12039075 | pubmed:author | pubmed-author:HamelLL | lld:pubmed |
| pubmed-article:12039075 | pubmed:author | pubmed-author:ChevalierSS | lld:pubmed |
| pubmed-article:12039075 | pubmed:author | pubmed-author:BéginL RLR | lld:pubmed |
| pubmed-article:12039075 | pubmed:author | pubmed-author:YUH SHS | lld:pubmed |
| pubmed-article:12039075 | pubmed:author | pubmed-author:AprikianA GAG | lld:pubmed |
| pubmed-article:12039075 | pubmed:author | pubmed-author:DefoyII | lld:pubmed |
| pubmed-article:12039075 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12039075 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:12039075 | pubmed:volume | 189 | lld:pubmed |
| pubmed-article:12039075 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12039075 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12039075 | pubmed:pagination | 169-79 | lld:pubmed |
| pubmed-article:12039075 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12039075 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12039075 | pubmed:articleTitle | Vascular endothelial growth factor and signaling in the prostate: more than angiogenesis. | lld:pubmed |
| pubmed-article:12039075 | pubmed:affiliation | Urologic Oncology Research Group, Department of Surgery, Urology Division, Research Institute, McGill University Health Center, 1650 Cedar Avenue, Quebec, H3G IA4, Montreal, Canada. simone.chevalier@mcgill.ca | lld:pubmed |
| pubmed-article:12039075 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12039075 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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