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pubmed-article:12036327pubmed:abstractTextThe complete nucleotide sequences of the medium (M) segment of seven Chinese isolates of Crimean-Congo hemorrhagic fever (CCHF) virus were determined. The M-segment RNA of CCHF virus comprises 5356-5377 nucleotides depending on the isolate and encodes a protein comprising 1689-1697 amino acids in a viral complementary sense. Phylogenetic analysis of the M segment showed that the Chinese CCHF virus isolates were clustered into three groups, one of which was more closely related to a Nigerian isolate. Pairwise comparison of a precursor protein showed that amino-terminal regions comprising 250 amino acids were extraordinary heterogeneous, with a 22.4% identity in amino acids being observed between the most distantly related isolates. Since all the viruses were isolated from 1966 to 1988 within a restricted area in the Xinjiang Autonomous Region in western China, the results indicate that a multisource virus population is endemic in this region.lld:pubmed
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pubmed-article:12036327pubmed:pagination159-64lld:pubmed
pubmed-article:12036327pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:12036327pubmed:articleTitleGenetic diversity of the M RNA segment among Crimean-Congo hemorrhagic fever virus isolates in China.lld:pubmed
pubmed-article:12036327pubmed:affiliationSpecial Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan. morikawa@nih.go.jplld:pubmed
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