| pubmed-article:12033737 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12033737 | lifeskim:mentions | umls-concept:C1515126 | lld:lifeskim |
| pubmed-article:12033737 | lifeskim:mentions | umls-concept:C0679006 | lld:lifeskim |
| pubmed-article:12033737 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:12033737 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12033737 | pubmed:dateCreated | 2002-5-29 | lld:pubmed |
| pubmed-article:12033737 | pubmed:abstractText | Cell-fate decisions are controlled typically by conserved receptors that interact with co-evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T cells into CD4+ or CD8+ mature T cells is unusual in that it is regulated by clonally expressed, somatically generated T-cell receptors (TCRs) of unpredictable fine specificity. Yet, each mature T cell generally retains expression of the co-receptor molecule (CD4 or CD8) that has an MHC-binding property that matches that of its TCR. Two models were proposed initially to explain this remarkable outcome--'instruction' of lineage choice by initial signalling events or 'selection' after a stochastic fate decision that limits further development to cells with coordinated TCR and co-receptor specificities. Aspects of both models now appear to be correct; mistake-prone instruction of lineage choice precedes a subsequent selection step that filters out most incorrect decisions. | lld:pubmed |
| pubmed-article:12033737 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12033737 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12033737 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12033737 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12033737 | pubmed:month | May | lld:pubmed |
| pubmed-article:12033737 | pubmed:issn | 1474-1733 | lld:pubmed |
| pubmed-article:12033737 | pubmed:author | pubmed-author:GermainRonald... | lld:pubmed |
| pubmed-article:12033737 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12033737 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:12033737 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12033737 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12033737 | pubmed:pagination | 309-22 | lld:pubmed |
| pubmed-article:12033737 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:12033737 | pubmed:meshHeading | pubmed-meshheading:12033737... | lld:pubmed |
| pubmed-article:12033737 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12033737 | pubmed:articleTitle | T-cell development and the CD4-CD8 lineage decision. | lld:pubmed |
| pubmed-article:12033737 | pubmed:affiliation | Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA. rgermain@nih.gov | lld:pubmed |
| pubmed-article:12033737 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12033737 | pubmed:publicationType | Review | lld:pubmed |
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