| pubmed-article:12029377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C0006644 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C0001480 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C1419778 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12029377 | lifeskim:mentions | umls-concept:C2346927 | lld:lifeskim |
| pubmed-article:12029377 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12029377 | pubmed:dateCreated | 2002-5-24 | lld:pubmed |
| pubmed-article:12029377 | pubmed:abstractText | The block of rabbit skeletal ryanodine receptors (RyR1) and dog heart RyR2 by cytosolic [Mg2+], and its reversal by agonists Ca2+, ATP and caffeine was studied in planar bilayers. Mg2+ effects were tested at submaximal activating [Ca2+] (5 microM). Approximately one third of the RyR1s had low open probability ("LA channels") in the absence of Mg2+. All other RyR1s displayed higher activity ("HA channels"). Cytosolic Mg2+ (1 mM) blocked individual RyR1 channels to varying degrees (32 to 100%). LA channels had residual P(o) <0.005 in 1 mM Mg2+ and reactivated poorly with [Ca2+] (100 microM), caffeine (5 mM), or ATP (4 mM; all at constant 1 mM Mg2+). HA channels had variable activity in Mg2+ and variable degree of recovery from Mg2+ block with Ca2+, caffeine or ATP application. Nearly all cardiac RyR2s displayed high activity in 5 microM [Ca2+]. They also had variable sensitivity to Mg2+. However, the RyR2s consistently recovered from Mg2+ block with 100 microM [Ca2+] or caffeine application, but not when ATP was added. Thus, at physiological [Mg2+], RyR2s behaved as relatively homogeneous Ca2+/caffeine-gated HA channels. In contrast, RyR1s displayed functional heterogeneity that arises from differential modulatory actions of Ca2+ and ATP. These differences between RyR1 and RyR2 function may reflect their respective roles in muscle physiology and excitation-contraction coupling. | lld:pubmed |
| pubmed-article:12029377 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12029377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12029377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12029377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12029377 | pubmed:month | May | lld:pubmed |
| pubmed-article:12029377 | pubmed:issn | 0022-2631 | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:FleischerSS | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:PortaMM | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:SchindlerHH | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:FillMM | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:BargSS | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:SonnleitnerAA | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:CopelloJ AJA | lld:pubmed |
| pubmed-article:12029377 | pubmed:author | pubmed-author:Diaz-Sylveste... | lld:pubmed |
| pubmed-article:12029377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12029377 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12029377 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:12029377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12029377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12029377 | pubmed:pagination | 51-64 | lld:pubmed |
| pubmed-article:12029377 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:meshHeading | pubmed-meshheading:12029377... | lld:pubmed |
| pubmed-article:12029377 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12029377 | pubmed:articleTitle | Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+. | lld:pubmed |
| pubmed-article:12029377 | pubmed:affiliation | Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA. jcopell@lumc.edu | lld:pubmed |
| pubmed-article:12029377 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12029377 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12029377 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12029377 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12029377 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12029377 | lld:pubmed |
