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pubmed-article:12028022pubmed:dateCreated2002-5-24lld:pubmed
pubmed-article:12028022pubmed:abstractTextFew cytogenetic data are available concerning the chromosomal constitution of post-transplant lymphomas. We report two paediatric cases of trisomy 3, as a primary anomaly, in post-transplant lymphoproliferative disease (PTLD) associated with B immunophenotype. Using cytogenetic analysis and fluorescence in situ hybridization on chromosome preparations, we found trisomy 3 in both patients and an extra X chromosome in one. Clinical, histological and immunophenotypical data are presented. Trisomy 3 has been observed in different types of non-Hodgkin's lymphomas but it is relatively rare in B-cell lymphomas, with the exception of marginal zone lymphoma and mantle cell lymphoma. To our knowledge, trisomy 3 is an uncommon cytogenetic finding in PTLD. Further cytogenetic studies of these lymphoproliferative disorders might contribute to evaluate the role of these chromosomal anomalies in the pathogenesis of this disease.lld:pubmed
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pubmed-article:12028022pubmed:authorpubmed-author:GallegoMarta...lld:pubmed
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pubmed-article:12028022pubmed:volume117lld:pubmed
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pubmed-article:12028022pubmed:pagination558-62lld:pubmed
pubmed-article:12028022pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:12028022pubmed:year2002lld:pubmed
pubmed-article:12028022pubmed:articleTitleTrisomy 3 in two paediatric post-transplant lymphomas.lld:pubmed
pubmed-article:12028022pubmed:affiliationCytogenetics Laboratory, Department of Genetics, Prof. Dr. Juan B. Garrahan Pediatric Hospital, Combate de los Pozos 1881, Buenos Aires C.P 1245, Argentina. msgall@intramed.net.arlld:pubmed
pubmed-article:12028022pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12028022pubmed:publicationTypeCase Reportslld:pubmed