| pubmed-article:12023307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12023307 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12023307 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:12023307 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12023307 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12023307 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:12023307 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:12023307 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12023307 | pubmed:dateCreated | 2002-5-22 | lld:pubmed |
| pubmed-article:12023307 | pubmed:abstractText | Axin, APC, and the kinase GSK3 beta are part of a destruction complex that regulates the stability of the Wnt pathway effector beta-catenin. In C. elegans, several Wnt-controlled developmental processes have been described, but an Axin ortholog has not been found in the genome sequence and SGG-1/GSK3 beta, and the APC-related protein APR-1 have been shown to act in a positive, rather than negative fashion in Wnt signaling. We have shown previously that the EGL-20/Wnt-dependent expression of the homeobox gene mab-5 in the Q neuroblast lineage requires BAR-1/beta-catenin and POP-1/Tcf. Here, we have investigated how BAR-1 is regulated by the EGL-20 pathway. First, we have characterized a negative regulator of the EGL-20 pathway, pry-1. We show that pry-1 encodes an RGS and DIX domain-containing protein that is distantly related to Axin/Conductin. Our results demonstrate that despite its sequence divergence, PRY-1 is a functional Axin homolog. We show that PRY-1 interacts with BAR-1, SGG-1, and APR-1 and that overexpression of PRY-1 inhibits mab-5 expression. Furthermore, pry-1 rescues the zebrafish axin1 mutation masterblind, showing that it can functionally interact with vertebrate destruction complex components. Finally, we show that SGG-1, in addition to its positive regulatory role in early embryonic Wnt signaling, may function as a negative regulator of the EGL-20 pathway. We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans. | lld:pubmed |
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| pubmed-article:12023307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12023307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12023307 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12023307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12023307 | pubmed:month | May | lld:pubmed |
| pubmed-article:12023307 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:12023307 | pubmed:author | pubmed-author:CleversHans... | lld:pubmed |
| pubmed-article:12023307 | pubmed:author | pubmed-author:KorswagenHend... | lld:pubmed |
| pubmed-article:12023307 | pubmed:author | pubmed-author:CoudreuseDami... | lld:pubmed |
