| pubmed-article:12021084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12021084 | lifeskim:mentions | umls-concept:C0242767 | lld:lifeskim |
| pubmed-article:12021084 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:12021084 | lifeskim:mentions | umls-concept:C1186763 | lld:lifeskim |
| pubmed-article:12021084 | lifeskim:mentions | umls-concept:C1880198 | lld:lifeskim |
| pubmed-article:12021084 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:12021084 | pubmed:dateCreated | 2002-5-21 | lld:pubmed |
| pubmed-article:12021084 | pubmed:abstractText | Recent successes in treating type 1 diabetic patients with islet transplantation portends a future need for an increase in available islets. Ductal structures of the adult pancreas contain multipotent stem cells that, under the proper in vitro conditions, can both self-renew and differentiate into functional islets of Langerhans. In vitro-generated islets exhibit temporal changes in mRNA transcripts for islet-associated markers as well as regulated insulin responses following glucose challenge. When implanted into diabetic mice, in vitro-generated islets induce neovascularization and reverse insulin-dependent diabetes. The possibility of growing functional endocrine pancreas from stem cells provides new opportunities to produce large numbers of islets, even autologous islets, for use as implants. | lld:pubmed |
| pubmed-article:12021084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12021084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12021084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12021084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12021084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12021084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12021084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12021084 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12021084 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:12021084 | pubmed:author | pubmed-author:PeckA BAB | lld:pubmed |
| pubmed-article:12021084 | pubmed:author | pubmed-author:ChaudhariMM | lld:pubmed |
| pubmed-article:12021084 | pubmed:author | pubmed-author:CorneliusJ... | lld:pubmed |
| pubmed-article:12021084 | pubmed:author | pubmed-author:ShatzDD | lld:pubmed |
| pubmed-article:12021084 | pubmed:author | pubmed-author:RamiyaV KVK | lld:pubmed |
| pubmed-article:12021084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12021084 | pubmed:volume | 958 | lld:pubmed |
| pubmed-article:12021084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12021084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12021084 | pubmed:pagination | 59-68 | lld:pubmed |
| pubmed-article:12021084 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:12021084 | pubmed:meshHeading | pubmed-meshheading:12021084... | lld:pubmed |
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| pubmed-article:12021084 | pubmed:meshHeading | pubmed-meshheading:12021084... | lld:pubmed |
| pubmed-article:12021084 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12021084 | pubmed:articleTitle | Use of in vitro-generated, stem cell-derived islets to cure type 1 diabetes: how close are we? | lld:pubmed |
| pubmed-article:12021084 | pubmed:affiliation | Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA. peck@pathology.ufl.edu | lld:pubmed |
| pubmed-article:12021084 | pubmed:publicationType | Journal Article | lld:pubmed |
