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pubmed-article:12020425pubmed:abstractTextTo investigate the G2 chromosomal radiosensitivity of patients with cancers diagnosed when the patients are less than 20 years of age. Earlier studies demonstrated an enhanced sensitivity in substantial proportions of patients with breast or colorectal cancer, and in early onset head and neck cancer cases. Heritability of chromosomal radiosensitivity in families of breast cancer patients was also demonstrated. It is suggested that elevated sensitivity in this assay could be a marker of genetic predisposition to cancer, mediated through inherited genetic determinants of low penetrance.lld:pubmed
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pubmed-article:12020425pubmed:articleTitleChromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition.lld:pubmed
pubmed-article:12020425pubmed:affiliationPaterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.lld:pubmed
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