| pubmed-article:12019166 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C0597032 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:12019166 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12019166 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12019166 | pubmed:dateCreated | 2002-5-20 | lld:pubmed |
| pubmed-article:12019166 | pubmed:abstractText | Systemic or local administration of cytokine has been used as a mode to enhance the antitumor immune response induced by many cancer vaccines. We have investigated whether the expression of cytokines on the tumor cell surface as a glycolipid (GPI)-anchored form will be effective in inducing antitumor immune response using a GPI-anchored interleukin (IL)-12 (GPI-IL-12) as a model. GPI-IL-12-induced the proliferation of concanavalin A-activated T cells and induced IFN-gamma secretion by activated and allogeneic T cells, indicating that the membrane-expressed IL-12 can stimulate T cells. GPI-IL-12 expressed on the tumor cell surface prevented tumor growth in mice in a highly tumorigenic murine mastocytoma model. These results suggest that the cell surface-expressed GPI-IL-12 can be effective in inducing antitumor immune response, and GPI-anchored cytokines expressed on the tumor cell surface may be a novel approach to deliver cytokines at the immunization site during vaccination against cancer. Furthermore, purified GPI-anchored cytokines can be used to quickly modify tumor membranes by the protein transfer method to express the desired cytokines for vaccine development. | lld:pubmed |
| pubmed-article:12019166 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12019166 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12019166 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12019166 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12019166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12019166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12019166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12019166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12019166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12019166 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12019166 | pubmed:month | May | lld:pubmed |
| pubmed-article:12019166 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:12019166 | pubmed:author | pubmed-author:NagarajanShan... | lld:pubmed |
| pubmed-article:12019166 | pubmed:author | pubmed-author:SelvarajPeria... | lld:pubmed |
| pubmed-article:12019166 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12019166 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12019166 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:12019166 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12019166 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12019166 | pubmed:pagination | 2869-74 | lld:pubmed |
| pubmed-article:12019166 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12019166 | pubmed:meshHeading | pubmed-meshheading:12019166... | lld:pubmed |
| pubmed-article:12019166 | pubmed:meshHeading | pubmed-meshheading:12019166... | lld:pubmed |
| pubmed-article:12019166 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12019166 | pubmed:articleTitle | Glycolipid-anchored IL-12 expressed on tumor cell surface induces antitumor immune response. | lld:pubmed |
| pubmed-article:12019166 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA. | lld:pubmed |
| pubmed-article:12019166 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12019166 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12019166 | lld:pubmed |
