| pubmed-article:12016136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0039065 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12016136 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12016136 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12016136 | pubmed:dateCreated | 2002-5-17 | lld:pubmed |
| pubmed-article:12016136 | pubmed:abstractText | The calcium-binding protein neuronal calcium sensor 1 (NCS-1) is involved in modulation of neurotransmitter release in the peripheral and central nervous systems. Since intestinal inflammation impairs neurotransmitter release, we evaluated the expression of NCS-1 in the normal rat colon and in dinitrobenzene sulfonic acid (DNBS)-induced colitis. Immunocytochemistry and Western blots showed high levels of NCS-1 in the myenteric plexus and in axons in the smooth muscle layers; 23 +/- 2% of myenteric neurons were NCS-1 positive, with staining restricted to the largest neurons. NCS-1-positive axons decreased to 13.3 +/- 0.4% of total axons by day 2 and dropped further to 7.0 +/- 0.1% by day 4, returning to control levels by day 16. Dual-label Western blot analysis showed that the expression of NCS-1 relative to PGP 9.5 decreased by 50% on day 4 but returned to control by day 16. The selective loss of NCS-1 during colitis may underlie the altered neural function seen in the inflamed intestine. | lld:pubmed |
| pubmed-article:12016136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12016136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016136 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12016136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12016136 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12016136 | pubmed:issn | 0193-1857 | lld:pubmed |
| pubmed-article:12016136 | pubmed:author | pubmed-author:RoderJJ | lld:pubmed |
| pubmed-article:12016136 | pubmed:author | pubmed-author:JerominAA | lld:pubmed |
| pubmed-article:12016136 | pubmed:author | pubmed-author:Blennerhasset... | lld:pubmed |
| pubmed-article:12016136 | pubmed:author | pubmed-author:LourenssenSS | lld:pubmed |
| pubmed-article:12016136 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12016136 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:12016136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12016136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12016136 | pubmed:pagination | G1097-104 | lld:pubmed |
| pubmed-article:12016136 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
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| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
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| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
| pubmed-article:12016136 | pubmed:meshHeading | pubmed-meshheading:12016136... | lld:pubmed |
| pubmed-article:12016136 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12016136 | pubmed:articleTitle | Intestinal inflammation modulates expression of the synaptic vesicle protein neuronal calcium sensor-1. | lld:pubmed |
| pubmed-article:12016136 | pubmed:affiliation | Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario, Canada. | lld:pubmed |
| pubmed-article:12016136 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:65153 | entrezgene:pubmed | pubmed-article:12016136 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12016136 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12016136 | lld:pubmed |
