| pubmed-article:12014950 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C0021533 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C0030016 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C1551022 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12014950 | lifeskim:mentions | umls-concept:C1961136 | lld:lifeskim |
| pubmed-article:12014950 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12014950 | pubmed:dateCreated | 2002-5-16 | lld:pubmed |
| pubmed-article:12014950 | pubmed:abstractText | Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme that is involved in the de novo synthesis of purine nucleotides. Novel 2-aminooxazoles were synthesized and tested for inhibition of IMPDH catalytic activity. Multiple analogues based on this chemotype were found to inhibit IMPDH with low nanomolar potency. One of the analogues (compound 23) showed excellent in vivo activity in the inhibition of antibody production in mice and in the adjuvant induced arthritis model in rats. | lld:pubmed |
| pubmed-article:12014950 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12014950 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12014950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12014950 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12014950 | pubmed:month | May | lld:pubmed |
| pubmed-article:12014950 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:WitmerMark... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:ZhaoRulinR | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:BarrishJoel... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:GuHenry HHH | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:IwanowiczEdwi... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:GuoJunqingJ | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:WattersonScot... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:ShenZhongqiZ | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:PittsWilliam... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:DharT G... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:FleenerCather... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:SherbinaN ZNZ | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:ChenBang-ChiB... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:LiuChunjianC | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:RouleauKather... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:McIntyreKim... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:ShusterDavid... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:TredupJeffrey... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:BednarzMark... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:CheneyDaniel... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:MacMasterJohn... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:MillerLaura... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:BerryKaren... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:HarperTimothy... | lld:pubmed |
| pubmed-article:12014950 | pubmed:author | pubmed-author:HollenbaughDi... | lld:pubmed |
| pubmed-article:12014950 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12014950 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:12014950 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:12014950 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12014950 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12014950 | pubmed:pagination | 2127-30 | lld:pubmed |
| pubmed-article:12014950 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:meshHeading | pubmed-meshheading:12014950... | lld:pubmed |
| pubmed-article:12014950 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12014950 | pubmed:articleTitle | Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity. | lld:pubmed |
| pubmed-article:12014950 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12014950 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12014950 | lld:pubmed |
