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pubmed-article:12014507pubmed:abstractTextTwo young adult Macaca fascicularis each had unilateral mydriasis and ptosis. Both animals were euthanatized, monkey No. I for progressive neurologic signs and monkey No. 2 because of a positive intradermal tuberculin test. At necropsy, each animal had a single intracranial mass on the ventral surface of the midbrain, surrounding the oculomotor nerve. Histologically, both masses were immunoblastic lymphomas. Immunohistochemical staining revealed the neoplasms to be of B-cell origin. Simian retrovirus (SRV) was isolated from both monkeys, but simian immunodeficiency virus was not found. Both animals lacked antibody to SRV. Both animals had antibodies to Epstein-Barr-like virus (EBV), but EBV antigens were not found by immunohistochemistry. Polymerase chain reaction analysis for integrated EBV DNA was unproductive. One of the animals (monkey No. 2) had a pulmonary infection with Mycobacterium avium, suggesting that immunosuppression was present. These cases represent a unique and previously undescribed type of solitary lymphoma in SRV-infected macaques.lld:pubmed
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pubmed-article:12014507pubmed:authorpubmed-author:WallaceJ MJMlld:pubmed
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pubmed-article:12014507pubmed:pagination399-402lld:pubmed
pubmed-article:12014507pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:12014507pubmed:year2002lld:pubmed
pubmed-article:12014507pubmed:articleTitleIntracranial lymphomas in simian retrovirus-positive Macaca fascicularis.lld:pubmed
pubmed-article:12014507pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12014507pubmed:publicationTypeCase Reportslld:pubmed