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pubmed-article:12011654pubmed:abstractTextThe baroreflex, which is important for the minute-to-minute regulation of blood pressure and heart rate, is influenced by genetic variance. Ion channels are important to baroreflex afferent and efferent function. Mice missing the beta1 subunit of the Ca2+-sensitive potassium channel (BK) are hypertensive and have a reset baroreflex. We tested the hypothesis that variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function.lld:pubmed
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pubmed-article:12011654pubmed:articleTitleThe BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation.lld:pubmed
pubmed-article:12011654pubmed:affiliationHELIOS Klinikum-Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany.lld:pubmed
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