| pubmed-article:12009529 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12009529 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:12009529 | lifeskim:mentions | umls-concept:C0966511 | lld:lifeskim |
| pubmed-article:12009529 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12009529 | lifeskim:mentions | umls-concept:C0815024 | lld:lifeskim |
| pubmed-article:12009529 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12009529 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:12009529 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12009529 | pubmed:dateCreated | 2002-5-15 | lld:pubmed |
| pubmed-article:12009529 | pubmed:abstractText | An unbiased functional screening with brain cDNA library from an Alzheimer's disease (AD) brain identified a novel 24-residue peptide Humanin (HN), which suppresses AD-related neurotoxicity. As the 1567-base cDNA containing the open reading frame (ORF) of HN is 99% identical to mitochondrial 16S ribosomal RNA as well as registered human mRNA, it was elusive whether HN is produced in vivo. Here, we raised anti-HN antibody and found that long cDNAs containing the ORF of HN (HN-ORF) produced the HN peptide in mammalian cells, dependent on the presence of full-length HN-ORF. Immunoblot analysis detected a 3-kDa protein with HN immunoreactivity in the testis and the colon in 3-week-old mice and in the testis in 12-week-old mice. HN immunoreactivity was also detected in an AD brain, but little in normal brains. This study suggests that HN peptide could be produced in vivo, and would provide a novel insight into the pathophysiology of AD. | lld:pubmed |
| pubmed-article:12009529 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12009529 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12009529 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12009529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12009529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12009529 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12009529 | pubmed:month | May | lld:pubmed |
| pubmed-article:12009529 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:NishimotoIkuo... | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:HashimotoYuic... | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:YamazakiKazut... | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:NiikuraTakako... | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:ItoYukoY | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:KitaYoshikoY | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:TerashitaKenz... | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:KotoAtsuoA | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:AisoSadakazuS | lld:pubmed |
| pubmed-article:12009529 | pubmed:author | pubmed-author:TajimaHirohis... | lld:pubmed |
| pubmed-article:12009529 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12009529 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:12009529 | pubmed:volume | 324 | lld:pubmed |
| pubmed-article:12009529 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12009529 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12009529 | pubmed:pagination | 227-31 | lld:pubmed |
| pubmed-article:12009529 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12009529 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12009529 | pubmed:articleTitle | Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. | lld:pubmed |
| pubmed-article:12009529 | pubmed:affiliation | Department of Pharmacology and Neurosciences, KEIO University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. | lld:pubmed |
| pubmed-article:12009529 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12009529 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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