| pubmed-article:1200844 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1200844 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:1200844 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:1200844 | lifeskim:mentions | umls-concept:C0016698 | lld:lifeskim |
| pubmed-article:1200844 | lifeskim:mentions | umls-concept:C0001560 | lld:lifeskim |
| pubmed-article:1200844 | lifeskim:mentions | umls-concept:C0014282 | lld:lifeskim |
| pubmed-article:1200844 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1200844 | pubmed:dateCreated | 1976-2-9 | lld:pubmed |
| pubmed-article:1200844 | pubmed:abstractText | A group of 23 student volunteers were each inoculated intranasally with 400 IU of inactivated, freeze-dried A/England/42/72 vaccine. Only one volunteer showed a four-fold rise in serum HI antibody following immunization, and the mean increase in serum HI antibody (gmt) for all volunteers did not increase two-fold. Thirteen of the volunteers developed detectable levels of nasal wash neutralizing antibody after immunization; local antibody was most commonly found in volunteers who produced a detectable but less than four-fold fise in serum antibody titre, and who produced nasal washings with relatively high concentrations of protein and secretory IgA. Four weeks after immunization, the vaccinees and a matched group of control subjects were inoculated with attenuated A/England/42/72 (MRC-7) virus. Evidence of infection was found in 14 of 23 (61 per cent) of control subjects and in seven of 23 (30 per cent) of immunized volunteers. This result showed a significant protection (P = 0.04) against challenge virus infection for volunteers given intranasal vaccine. | lld:pubmed |
| pubmed-article:1200844 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1200844 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1200844 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1200844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1200844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1200844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1200844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1200844 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1200844 | pubmed:issn | 0304-8608 | lld:pubmed |
| pubmed-article:1200844 | pubmed:author | pubmed-author:PotterC WCW | lld:pubmed |
| pubmed-article:1200844 | pubmed:author | pubmed-author:ClarkeAA | lld:pubmed |
| pubmed-article:1200844 | pubmed:author | pubmed-author:JenningsRR | lld:pubmed |
| pubmed-article:1200844 | pubmed:author | pubmed-author:McLarenCC | lld:pubmed |
| pubmed-article:1200844 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1200844 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:1200844 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1200844 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1200844 | pubmed:pagination | 307-16 | lld:pubmed |
| pubmed-article:1200844 | pubmed:dateRevised | 2005-11-22 | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:meshHeading | pubmed-meshheading:1200844-... | lld:pubmed |
| pubmed-article:1200844 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1200844 | pubmed:articleTitle | Immunity following intranasal administration of an inactivated, freeze-dried A/England/42/72 vaccine. | lld:pubmed |
| pubmed-article:1200844 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1200844 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1200844 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1200844 | lld:pubmed |
