| pubmed-article:12006367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C0015688 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C0596620 | lld:lifeskim |
| pubmed-article:12006367 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:12006367 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12006367 | pubmed:dateCreated | 2002-5-13 | lld:pubmed |
| pubmed-article:12006367 | pubmed:abstractText | The effects of insulin-like growth factor I (IGF-I) and insulin on free fatty acid (FFA) and glucose metabolism were compared in eight control and eight type 2 diabetic subjects, who received a two-step euglycemic hyperinsulinemic (0.25 and 0.5 mU x kg(-1) x min(-1)) clamp and a two-step euglycemic IGF-I (26 and 52 pmol x kg(-1) x min(-1)) clamp with [3-(3)H]glucose, [1-(14)C]palmitate, and indirect calorimetry. The insulin and IGF-I infusion rates were chosen to augment glucose disposal (R(d)) to a similar extent in control subjects. In type 2 diabetic subjects, stimulation of R(d) (second clamp step) in response to both insulin and IGF-I was reduced by approximately 40-50% compared with control subjects. In control subjects, insulin was more effective than IGF-I in suppressing endogenous glucose production (EGP) during both clamp steps. In type 2 diabetic subjects, insulin-mediated suppression of EGP was impaired, whereas EGP suppression by IGF-I was similar to that of controls. In both control and diabetic subjects, IGF-I-mediated suppression of plasma FFA concentration and inhibition of FFA turnover were markedly impaired compared with insulin (P < 0.01-0.001). During the second IGF-I clamp step, suppression of plasma FFA concentration and FFA turnover was impaired in diabetic vs. control subjects (P < 0.05-0.01). CONCLUSIONS: 1) IGF-I is less effective than insulin in suppressing EGP and FFA turnover; 2) insulin-resistant type 2 diabetic subjects also exhibit IGF-I resistance in skeletal muscle. However, suppression of EGP by IGF-I is not impaired in diabetic individuals, indicating normal hepatic sensitivity to IGF-I. | lld:pubmed |
| pubmed-article:12006367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12006367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12006367 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12006367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12006367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12006367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12006367 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12006367 | pubmed:issn | 0193-1849 | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:Pratipanawatr... | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:CusiKennethK | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:Pratipanawatr... | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:DeFronzoRalph... | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:RosenClifford... | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:BerriaRachele... | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:BajajMandeepM | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:MandarinoLawr... | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:KashyapSanget... | lld:pubmed |
| pubmed-article:12006367 | pubmed:author | pubmed-author:BelfortRenata... | lld:pubmed |
| pubmed-article:12006367 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12006367 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:12006367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12006367 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12006367 | pubmed:pagination | E1360-8 | lld:pubmed |
| pubmed-article:12006367 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:12006367 | pubmed:meshHeading | pubmed-meshheading:12006367... | lld:pubmed |
| pubmed-article:12006367 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12006367 | pubmed:articleTitle | Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects. | lld:pubmed |
| pubmed-article:12006367 | pubmed:affiliation | Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA. | lld:pubmed |
| pubmed-article:12006367 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12006367 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12006367 | lld:pubmed |
