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pubmed-article:11999409pubmed:abstractText3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) is known as a dietary carcinogen and it requires metabolic activation by cytochrome P450 (CYP) 1A subfamily to have carcinogenicity. On the other hand, our previous report demonstrated that Trp-P-1 induces apoptosis in primary cultured rat hepatocytes, but the metabolically activated Trp-P-1 added extracelluarly to hepatocytes did not induce apoptosis. In this study, we focused on the intracellular status of CYPs and investigated apoptotic events induced by Trp-P-1 using hepatocytes isolated from rats treated with three chemical inducers for CYPs. In cultured hepatocytes from rats treated with 3-methylchoranthrene, which mainly induces CYP 1A, Trp-P-1-induced apoptosis was suppressed. In the same cultures, intact Trp-P-1 was decreased and its metabolites were increased. Phenobarbital and pyridine did not affect Trp-P-1-induced apoptosis. These results suggested that evoking CYP 1A activity might interfere with apoptosis induced by Trp-P-1 in rat hepatocytes under the ex vivo system.lld:pubmed
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pubmed-article:11999409pubmed:authorpubmed-author:NonakaYujiYlld:pubmed
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pubmed-article:11999409pubmed:volume66lld:pubmed
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pubmed-article:11999409pubmed:pagination356-62lld:pubmed
pubmed-article:11999409pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11999409pubmed:articleTitleEvoking cytochrome P450 1A activity interferes with apoptosis induced by 3-amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) in rat hepatocytes under the ex vivo system.lld:pubmed
pubmed-article:11999409pubmed:affiliationDivision of Life Science, Graduate School of Science and Technology, Kobe University, Japan.lld:pubmed
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pubmed-article:11999409pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed