| pubmed-article:11989809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11989809 | lifeskim:mentions | umls-concept:C0034798 | lld:lifeskim |
| pubmed-article:11989809 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11989809 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:11989809 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11989809 | lifeskim:mentions | umls-concept:C1621296 | lld:lifeskim |
| pubmed-article:11989809 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:11989809 | lifeskim:mentions | umls-concept:C0439611 | lld:lifeskim |
| pubmed-article:11989809 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11989809 | pubmed:dateCreated | 2002-5-6 | lld:pubmed |
| pubmed-article:11989809 | pubmed:abstractText | A series of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes were synthesized and evaluated for their binding affinity toward D1-like and D2-like dopamine (DA) receptors. The affinity and selectivity of these compounds were measured in a test involving displacement of [3H]SCH 23390 or [3H]YM-09-151-2, respectively, from homogenates of porcine striatal membranes. All tested compounds were poorly effective at DA receptors (Ki nM > 1000). The results suggest that introduction of chlorine substituent in five or six position of previously synthesized trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes decreases both D1-like and D2-like receptor affinity. | lld:pubmed |
| pubmed-article:11989809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11989809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11989809 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11989809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11989809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11989809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11989809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11989809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11989809 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11989809 | pubmed:issn | 0014-827X | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:CostaBarbaraB | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:LucacchiniAnt... | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:MartiniClaudi... | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:PinnenFrances... | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:SozioPieraP | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:LuisiGraziaG | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:CacciatoreIva... | lld:pubmed |
| pubmed-article:11989809 | pubmed:author | pubmed-author:MosciattiBarb... | lld:pubmed |
| pubmed-article:11989809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11989809 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:11989809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11989809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11989809 | pubmed:pagination | 303-13 | lld:pubmed |
| pubmed-article:11989809 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:meshHeading | pubmed-meshheading:11989809... | lld:pubmed |
| pubmed-article:11989809 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11989809 | pubmed:articleTitle | Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands. | lld:pubmed |
| pubmed-article:11989809 | pubmed:affiliation | Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti, Italy. adistefano@unich.it | lld:pubmed |
| pubmed-article:11989809 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11989809 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11989809 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
