| pubmed-article:11986952 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11986952 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11986952 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11986952 | pubmed:dateCreated | 2002-5-2 | lld:pubmed |
| pubmed-article:11986952 | pubmed:abstractText | Phosphatidylinositol (PI) 3-kinase plays an important role in a variety of biological processes, including proliferation and apoptosis. PI3-kinase is a heterodimer consisting of an 85 kDa adapter protein (p85) containing one SH3 domain and two SH2 domains and a 110 kDa catalytic subunit (p110). Recently an oncogenic form of p85 named p65-PI3K lacking the C-terminal SH2 domain has been cloned from an irradiation-induced murine thymic lymphoma and transgenic mice expressing p65-PI3K in T lymphocytes develop a lymphoproliferative disorder. Here we describe the cloning of a C-terminal truncated form of p85 expressed in a human lymphoma cell line (CO) with a T cell phenotype derived from a patient with Hodgkin's disease. As a result of a frame-shift mutation at amino acid 636, p76 is lacking most of the C-terminal SH2 domain, but contains the inter-SH2 domain and is associated with an active form of PI3-kinase. A PI3-kinase-dependent constitutive activation of Akt was detected in CO cells which was only partially reduced after serum starvation. Treatment of CO cells with the PI3-kinase inhibitor wortmannin resulted in a concentration-dependent inhibition of cell proliferation associated with an increased number of apoptotic cells. This is the first detection of a mutated form of the p85 subunit of PI3-kinase in human hematopoietic cells further underlining a potential role of PI3-kinase/Akt signaling in human leukemogenesis. | lld:pubmed |
| pubmed-article:11986952 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11986952 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11986952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986952 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11986952 | pubmed:month | May | lld:pubmed |
| pubmed-article:11986952 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:11986952 | pubmed:author | pubmed-author:FiedlerWW | lld:pubmed |
| pubmed-article:11986952 | pubmed:author | pubmed-author:FeldmanR ARA | lld:pubmed |
| pubmed-article:11986952 | pubmed:author | pubmed-author:HornSS | lld:pubmed |
| pubmed-article:11986952 | pubmed:author | pubmed-author:WegnerWW | lld:pubmed |
| pubmed-article:11986952 | pubmed:author | pubmed-author:JückerMM | lld:pubmed |
| pubmed-article:11986952 | pubmed:author | pubmed-author:SickelMM | lld:pubmed |
| pubmed-article:11986952 | pubmed:author | pubmed-author:SüdelKK | lld:pubmed |
| pubmed-article:11986952 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11986952 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:11986952 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11986952 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11986952 | pubmed:pagination | 894-901 | lld:pubmed |
| pubmed-article:11986952 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11986952 | pubmed:meshHeading | pubmed-meshheading:11986952... | lld:pubmed |
| pubmed-article:11986952 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11986952 | pubmed:articleTitle | Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO). | lld:pubmed |
| pubmed-article:11986952 | pubmed:affiliation | Institut für Medizinische Biochemie und Molekularbiologie, Abteilung für Zelluläre Signaltransduktion, Universitätsklinikum Hamburg-Eppendorf, Universität Hamburg, Martinistrasse 52, 20246 Hamburg, Germany. | lld:pubmed |
| pubmed-article:11986952 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11986952 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11986952 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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