| pubmed-article:11981850 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C0012935 | lld:lifeskim |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C0311474 | lld:lifeskim |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C0032521 | lld:lifeskim |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C0037633 | lld:lifeskim |
| pubmed-article:11981850 | lifeskim:mentions | umls-concept:C0201699 | lld:lifeskim |
| pubmed-article:11981850 | pubmed:issue | 7-8 | lld:pubmed |
| pubmed-article:11981850 | pubmed:dateCreated | 2002-5-23 | lld:pubmed |
| pubmed-article:11981850 | pubmed:abstractText | We present a study of the separation of RNA, single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) in semidilute linear hydroxyethylcellulose (HEC) solution. Our results strive to provide a better understanding of the mechanisms of nucleic acid migration during electrophoresis in polymer solutions under native and denaturing conditions. From a study of the dependence of mobility on chain length and applied electric field, we found that RNA and ssDNA show better separation and higher resolution over a larger range of sizes compared to dsDNA. In addition, RNA reptation without orientation extends to longer chain lengths in comparison to ssDNA, possibly as a result of different type of short-lived secondary structure formations. Such a comparative study between nucleic acid capillary electrophoresis helps to optimize RNA separation and provides better understanding of RNA migration mechanisms in semidilute polymer solutions under denaturing conditions. | lld:pubmed |
| pubmed-article:11981850 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11981850 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11981850 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11981850 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11981850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11981850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11981850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11981850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11981850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11981850 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11981850 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11981850 | pubmed:issn | 0173-0835 | lld:pubmed |
| pubmed-article:11981850 | pubmed:author | pubmed-author:ROYR HRH | lld:pubmed |
| pubmed-article:11981850 | pubmed:author | pubmed-author:MorrisMichael... | lld:pubmed |
| pubmed-article:11981850 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11981850 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:11981850 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11981850 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11981850 | pubmed:pagination | 1033-44 | lld:pubmed |
| pubmed-article:11981850 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11981850 | pubmed:meshHeading | pubmed-meshheading:11981850... | lld:pubmed |
| pubmed-article:11981850 | pubmed:meshHeading | pubmed-meshheading:11981850... | lld:pubmed |
| pubmed-article:11981850 | pubmed:meshHeading | pubmed-meshheading:11981850... | lld:pubmed |
| pubmed-article:11981850 | pubmed:meshHeading | pubmed-meshheading:11981850... | lld:pubmed |
| pubmed-article:11981850 | pubmed:meshHeading | pubmed-meshheading:11981850... | lld:pubmed |
| pubmed-article:11981850 | pubmed:meshHeading | pubmed-meshheading:11981850... | lld:pubmed |
| pubmed-article:11981850 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11981850 | pubmed:articleTitle | Comparison of RNA, single-stranded DNA and double-stranded DNA behavior during capillary electrophoresis in semidilute polymer solutions. | lld:pubmed |
| pubmed-article:11981850 | pubmed:affiliation | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA. | lld:pubmed |
| pubmed-article:11981850 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11981850 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11981850 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
