| pubmed-article:11977978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11977978 | lifeskim:mentions | umls-concept:C0015914 | lld:lifeskim |
| pubmed-article:11977978 | lifeskim:mentions | umls-concept:C1160474 | lld:lifeskim |
| pubmed-article:11977978 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:11977978 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11977978 | pubmed:dateCreated | 2002-4-29 | lld:pubmed |
| pubmed-article:11977978 | pubmed:abstractText | A centrally important factor in initiating egg activation at fertilization is a rise in free Ca(2+) in the egg cytosol. In echinoderm, ascidian, and vertebrate eggs, the Ca(2+) rise occurs as a result of inositol trisphosphate-mediated release of Ca(2+) from the endoplasmic reticulum. The release of Ca(2+) at fertilization in echinoderm and ascidian eggs requires SH2 domain-mediated activation of a Src family kinase (SFK) and phospholipase C (PLC)gamma. Though some evidence indicates that a SFK and PLC may also function at fertilization in vertebrate eggs, SH2 domain-mediated activation of PLC gamma appears not to be required. Much work has focused on identifying factors from sperm that initiate egg activation at fertilization, either as a result of sperm-egg contact or sperm-egg fusion. Current evidence from studies of ascidian and mammalian fertilization favors a fusion-mediated mechanism; this is supported by experiments indicating that injection of sperm extracts into eggs causes Ca(2+) release by the same pathway as fertilization. | lld:pubmed |
| pubmed-article:11977978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11977978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11977978 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11977978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11977978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11977978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11977978 | pubmed:month | May | lld:pubmed |
| pubmed-article:11977978 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:11977978 | pubmed:author | pubmed-author:RunftLinda... | lld:pubmed |
| pubmed-article:11977978 | pubmed:author | pubmed-author:JaffeLaurinda... | lld:pubmed |
| pubmed-article:11977978 | pubmed:author | pubmed-author:MehlmannLisa... | lld:pubmed |
| pubmed-article:11977978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11977978 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11977978 | pubmed:volume | 245 | lld:pubmed |
| pubmed-article:11977978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11977978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11977978 | pubmed:pagination | 237-54 | lld:pubmed |
| pubmed-article:11977978 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11977978 | pubmed:meshHeading | pubmed-meshheading:11977978... | lld:pubmed |
| pubmed-article:11977978 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11977978 | pubmed:articleTitle | Egg activation at fertilization: where it all begins. | lld:pubmed |
| pubmed-article:11977978 | pubmed:affiliation | Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA. runft@lifesci.ucsb.edu | lld:pubmed |
| pubmed-article:11977978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11977978 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11977978 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:11977978 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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