| pubmed-article:11971957 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11971957 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:11971957 | lifeskim:mentions | umls-concept:C0036720 | lld:lifeskim |
| pubmed-article:11971957 | lifeskim:mentions | umls-concept:C0139030 | lld:lifeskim |
| pubmed-article:11971957 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11971957 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:11971957 | lifeskim:mentions | umls-concept:C0766831 | lld:lifeskim |
| pubmed-article:11971957 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11971957 | pubmed:dateCreated | 2002-4-24 | lld:pubmed |
| pubmed-article:11971957 | pubmed:abstractText | The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped all cAMP-induced phosphorylation sites in Raf-1, showing that serines 43, 259, and 621 are phosphorylated by PKA in vitro and induced by cAMP in vivo. Serine 43 phosphorylation decreased the binding to Ras in serum-starved but not in mitogen-stimulated cells. However, the kinase activity of a RafS43A mutant was fully inhibited by PKA. Mutation of serine 259 increased the basal Raf-1 activity and rendered it largely resistant to inhibition by PKA. cAMP increased Raf-1 serine 259 phosphorylation in a PKA-dependent manner with kinetics that correlated with ERK deactivation. PKA also decreased Raf-1 serine 338 phosphorylation of Raf-1, previously shown to be required for Raf-1 activation. Serine 338 phosphorylation of a RafS259A mutant was unaffected by PKA. Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for PKA inhibition of ERK and ERK-induced gene expression, and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation. | lld:pubmed |
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| pubmed-article:11971957 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11971957 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11971957 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11971957 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11971957 | pubmed:month | May | lld:pubmed |
| pubmed-article:11971957 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11971957 | pubmed:author | pubmed-author:MischakHarald... | lld:pubmed |
| pubmed-article:11971957 | pubmed:author | pubmed-author:DhillonAmarde... | lld:pubmed |
| pubmed-article:11971957 | pubmed:author | pubmed-author:KolchWalterW | lld:pubmed |
| pubmed-article:11971957 | pubmed:author | pubmed-author:ShawPeter EPE | lld:pubmed |
| pubmed-article:11971957 | pubmed:author | pubmed-author:PollockClaire... | lld:pubmed |
| pubmed-article:11971957 | pubmed:author | pubmed-author:SteenHelgeH | lld:pubmed |
| pubmed-article:11971957 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11971957 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:11971957 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11971957 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11971957 | pubmed:pagination | 3237-46 | lld:pubmed |
| pubmed-article:11971957 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11971957 | pubmed:meshHeading | pubmed-meshheading:11971957... | lld:pubmed |
| pubmed-article:11971957 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11971957 | pubmed:articleTitle | Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. | lld:pubmed |
| pubmed-article:11971957 | pubmed:affiliation | The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom. | lld:pubmed |
| pubmed-article:11971957 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11971957 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
