| pubmed-article:11971876 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C0344315 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C0015745 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C1332102 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C1415470 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C0443281 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:11971876 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:11971876 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11971876 | pubmed:dateCreated | 2002-4-24 | lld:pubmed |
| pubmed-article:11971876 | pubmed:abstractText | HAP-1 is a huntingtin-associated protein that is enriched in the brain. To gain insight into the normal physiological role of HAP-1, mice were generated with homozygous disruption at the Hap1 locus. Loss of HAP-1 expression did not alter the gross brain expression levels of its interacting partners, huntingtin and p150glued. Newborn Hap1(-/-) animals are observed at the expected Mendelian frequency suggesting a non-essential role of HAP-1 during embryogenesis. Postnatally, Hap1(-/-) pups show decreased feeding behavior that ultimately leads to malnutrition, dehydration and premature death. Seventy percent of Hap1(-/-) pups fail to survive past the second postnatal day (P2) and 100% of Hap1(-/-) pups fail to survive past P9. From P2 until death, Hap1(-/-) pups show markedly decreased amounts of ingested milk. Hap1(-/-) pups that survive to P8 show signs of starvation including greatly decreased serum leptin levels, decreased brain weight and atrophy of the brain cortical mantel. HAP-1 is particularly enriched in the hypothalamus, which is well documented to regulate feeding behavior. Our results demonstrate that HAP-1 plays an essential role in regulating postnatal feeding. | lld:pubmed |
| pubmed-article:11971876 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11971876 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11971876 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11971876 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11971876 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11971876 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:HaydenMichael... | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:GutekunstClai... | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:MetzlerMartin... | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:RossChristoph... | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:ChanEdmond... | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:GertsensteinM... | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:NasirJamalJ | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:ColemanSarahS | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:MacleanAlanA | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:MaasAlexA | lld:pubmed |
| pubmed-article:11971876 | pubmed:author | pubmed-author:NagyAndràsA | lld:pubmed |
| pubmed-article:11971876 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11971876 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11971876 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:11971876 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11971876 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11971876 | pubmed:pagination | 945-59 | lld:pubmed |
| pubmed-article:11971876 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11971876 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11971876 | pubmed:articleTitle | Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. | lld:pubmed |
| pubmed-article:11971876 | pubmed:affiliation | Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. | lld:pubmed |
| pubmed-article:11971876 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11971876 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11971876 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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