Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11970865rdf:typepubmed:Citationlld:pubmed
pubmed-article:11970865lifeskim:mentionsumls-concept:C0599851lld:lifeskim
pubmed-article:11970865lifeskim:mentionsumls-concept:C0031715lld:lifeskim
pubmed-article:11970865lifeskim:mentionsumls-concept:C0081889lld:lifeskim
pubmed-article:11970865lifeskim:mentionsumls-concept:C0441655lld:lifeskim
pubmed-article:11970865lifeskim:mentionsumls-concept:C0162493lld:lifeskim
pubmed-article:11970865lifeskim:mentionsumls-concept:C0086597lld:lifeskim
pubmed-article:11970865lifeskim:mentionsumls-concept:C0301039lld:lifeskim
pubmed-article:11970865pubmed:issue2lld:pubmed
pubmed-article:11970865pubmed:dateCreated2002-4-23lld:pubmed
pubmed-article:11970865pubmed:abstractTextActivity-regulated transcription has been implicated in adaptive plasticity in the CNS. In many instances, this plasticity depends upon the transcription factor CREB. Precisely how neuronal activity regulates CREB remains unclear. To address this issue, we examined the phosphorylation state of components of the CREB transcriptional pathway. We show that NMDA activates transcription of CREB-responsive genes in hippocampal neurons, with ERK responsible for persistent CREB phosphorylation and CaM kinase IV (CaMKIV) responsible for phosphorylating the CREB coactivator, CBP. Ser301 of CBP was identified as a major target of CaMKIV phosphorylation in vitro and in vivo. CaM kinase inhibitors attenuated phosphorylation at Ser301 and blocked CBP-dependent transcription. Additionally, mutation of Ser301 impaired NMDA- and CaMKIV-stimulated transcription. These findings demonstrate that activity-induced CaMKIV signaling contributes to CREB/CBP-dependent transcription by phosphorylating CBP at Ser301.lld:pubmed
pubmed-article:11970865pubmed:languageenglld:pubmed
pubmed-article:11970865pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:citationSubsetIMlld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11970865pubmed:statusMEDLINElld:pubmed
pubmed-article:11970865pubmed:monthAprlld:pubmed
pubmed-article:11970865pubmed:issn0896-6273lld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:StormDaniel...lld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:ObrietanKarlKlld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:ImpeySorenSlld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:GoodmanRichar...lld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:WangYanhongYlld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:WaymanGary...lld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:SoderlingThom...lld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:FongAmy LALlld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:CardinauxJean...lld:pubmed
pubmed-article:11970865pubmed:authorpubmed-author:FassDaniel...lld:pubmed
pubmed-article:11970865pubmed:issnTypePrintlld:pubmed
pubmed-article:11970865pubmed:day11lld:pubmed
pubmed-article:11970865pubmed:volume34lld:pubmed
pubmed-article:11970865pubmed:ownerNLMlld:pubmed
pubmed-article:11970865pubmed:authorsCompleteYlld:pubmed
pubmed-article:11970865pubmed:pagination235-44lld:pubmed
pubmed-article:11970865pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:meshHeadingpubmed-meshheading:11970865...lld:pubmed
pubmed-article:11970865pubmed:year2002lld:pubmed
pubmed-article:11970865pubmed:articleTitlePhosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV.lld:pubmed
pubmed-article:11970865pubmed:affiliationThe Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L-474, Portland, OR 97201, USA. impeys@ohsu.edulld:pubmed
pubmed-article:11970865pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11970865pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:11970865pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:1387entrezgene:pubmedpubmed-article:11970865lld:entrezgene
entrez-gene:814entrezgene:pubmedpubmed-article:11970865lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:11970865lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11970865lld:pubmed
More...