| pubmed-article:11960306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C0027567 | lld:lifeskim |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C1519427 | lld:lifeskim |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C0665952 | lld:lifeskim |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:11960306 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:11960306 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11960306 | pubmed:dateCreated | 2002-4-17 | lld:pubmed |
| pubmed-article:11960306 | pubmed:abstractText | Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two major ethnic groups (eg KIR2DS4 gene frequency 0.82 African, 0.47 S Asian. Pc < 1 x 10(-6)) and this is due to uneven distribution of two KIR haplotype families 'A' and 'B'. All three populations described here displayed a greater degree of diversity of KIR genetic profiles than other populations investigated, which indicates further complexity of underlying haplotypes; in this respect we describe two individuals who appear homozygous for a large deletion including the previously ubiquitous 2DL4. We have also reanalysed three populations that we studied previously, for the presence of a KIR which is now known to be an indicator of the 'B' haplotype. South Asians had the highest overall frequencies of all KIR loci characteristic of 'B' haplotypes (Pc < 0.0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations. | lld:pubmed |
| pubmed-article:11960306 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11960306 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11960306 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11960306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11960306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11960306 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11960306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11960306 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11960306 | pubmed:issn | 1466-4879 | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:VaughanR WRW | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:Chandanayingy... | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:CurranM DMD | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:HameedKK | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:RamdathD DDD | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:NormanP JPJ | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:VerityD HDH | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:CarringtonC... | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:ByngMM | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:MaxwellL DLD | lld:pubmed |
| pubmed-article:11960306 | pubmed:author | pubmed-author:StephensH A... | lld:pubmed |
| pubmed-article:11960306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11960306 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:11960306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11960306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11960306 | pubmed:pagination | 86-95 | lld:pubmed |
| pubmed-article:11960306 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11960306 | pubmed:meshHeading | pubmed-meshheading:11960306... | lld:pubmed |
| pubmed-article:11960306 | pubmed:meshHeading | pubmed-meshheading:11960306... | lld:pubmed |
| pubmed-article:11960306 | pubmed:meshHeading | pubmed-meshheading:11960306... | lld:pubmed |
| pubmed-article:11960306 | pubmed:meshHeading | pubmed-meshheading:11960306... | lld:pubmed |
| pubmed-article:11960306 | pubmed:meshHeading | pubmed-meshheading:11960306... | lld:pubmed |
| pubmed-article:11960306 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11960306 | pubmed:articleTitle | Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. | lld:pubmed |
| pubmed-article:11960306 | pubmed:affiliation | South Thames Tissue Typing, Guy's Hospital, London, UK. paul.norman@kcl.ac.uk | lld:pubmed |
| pubmed-article:11960306 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11960306 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11960306 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:115653 | entrezgene:pubmed | pubmed-article:11960306 | lld:entrezgene |
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