Linked Life Data

11959803

Source:http://linkedlifedata.com/resource/pubmed/id/11959803

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11959803rdf:typepubmed:Citationlld:pubmed
pubmed-article:11959803lifeskim:mentionsumls-concept:C0031330lld:lifeskim
pubmed-article:11959803lifeskim:mentionsumls-concept:C1999216lld:lifeskim
pubmed-article:11959803lifeskim:mentionsumls-concept:C0678640lld:lifeskim
pubmed-article:11959803lifeskim:mentionsumls-concept:C1533691lld:lifeskim
pubmed-article:11959803lifeskim:mentionsumls-concept:C0597484lld:lifeskim
pubmed-article:11959803lifeskim:mentionsumls-concept:C0679622lld:lifeskim
pubmed-article:11959803lifeskim:mentionsumls-concept:C0205314lld:lifeskim
pubmed-article:11959803lifeskim:mentionsumls-concept:C1515655lld:lifeskim
pubmed-article:11959803pubmed:issue8lld:pubmed
pubmed-article:11959803pubmed:dateCreated2002-4-17lld:pubmed
pubmed-article:11959803pubmed:abstractText1. We investigated the inhibitory effects of a non-acylguanidine Na(+)-H(+) exchange (NHE) inhibitor, T-162559 ((5E,7S)-[7-(5-fluoro-2-methylphenyl)-4-methyl-7,8-dihydro-5(6H)-quinolinylideneamino] guanidine dimethanesulphonate), on NHE-1, and its cardioprotective effect against ischaemia and reperfusion injury in rats and rabbits. 2. T-162559 inhibited human platelet NHE-1 in a concentration-dependent manner, with an IC(50) value of 13+/-3 nmol l(-1), making it 16 and three times more potent than cariporide IC(50): 209+/-75 nmol l(-1), P<0.01) and eniporide (IC(50): 40+/-11 nmol l(-1), P=0.066), respectively. T-162559 also inhibited rat NHE-1 with an IC(50) value of 14+/-2 nmol l(-1), which was five and three times lower than that of cariporide (IC(50): 75+/-7 nmol l(-1), P<0.01) and eniporide (IC(50): 44+/-2 nmol l(-1), P<0.01), respectively. 3. T-162559 inhibited, in a concentration-dependent manner, the reduction in cardiac contractility, progression of cardiac contracture, and increase in lactate dehydrogenase release after global ischaemia and reperfusion in perfused rat hearts. The inhibitory effects of T-162559 were observed at a lower concentration range (10 - 100 nmol l(-1)) than with cariporide and eniporide. T-162559 did not alter basal cardiac contractility or coronary flow after reperfusion, suggesting that it exerts direct cardioprotective effects on the heart. 4. Intravenous administration of T-162559 (0.03 and 0.1 mg kg(-1)) significantly inhibited the progression of myocardial infarction induced by left coronary artery occlusion and reperfusion in rabbits; the infarct size normalized by area at risk was 74+/-6% in the vehicle group, and 47+/-5% and 51+/-7% in the T-162559-0.03 mg kg(-1) and T-162559-0.1 mg kg(-1) groups (both P<0.05), respectively. 5. These results indicate that the new structural NHE-1 inhibitor T-162559 is more potent than cariporide and eniporide and possesses a cardioprotective effect against ischaemia and reperfusion injury in rat and rabbit models.lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:languageenglld:pubmed
pubmed-article:11959803pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:citationSubsetIMlld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11959803pubmed:statusMEDLINElld:pubmed
pubmed-article:11959803pubmed:monthAprlld:pubmed
pubmed-article:11959803pubmed:issn0007-1188lld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:JudsonIIlld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:KusumotoKeiji...lld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:AbeAkemiAlld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:IkedaShotaSlld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:TsuboiAyakoAlld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:ImamiyaEikohElld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:FukumotoShoji...lld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:ShiraishiMits...lld:pubmed
pubmed-article:11959803pubmed:authorpubmed-author:WatanabeToshi...lld:pubmed
pubmed-article:11959803pubmed:issnTypePrintlld:pubmed
pubmed-article:11959803pubmed:volume135lld:pubmed
pubmed-article:11959803pubmed:ownerNLMlld:pubmed
pubmed-article:11959803pubmed:authorsCompleteYlld:pubmed
pubmed-article:11959803pubmed:pagination1995-2003lld:pubmed
pubmed-article:11959803pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:meshHeadingpubmed-meshheading:11959803...lld:pubmed
pubmed-article:11959803pubmed:year2002lld:pubmed
pubmed-article:11959803pubmed:articleTitleIn vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559.lld:pubmed
pubmed-article:11959803pubmed:affiliationPharmacology Research Laboratories I, Takeda Chemical Industries, LTD., Osaka 532-8686, Japan. kusumoto_keiji@takeda.co.jplld:pubmed
More...