| pubmed-article:11959568 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11959568 | lifeskim:mentions | umls-concept:C0009184 | lld:lifeskim |
| pubmed-article:11959568 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11959568 | lifeskim:mentions | umls-concept:C0936148 | lld:lifeskim |
| pubmed-article:11959568 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:11959568 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:11959568 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11959568 | pubmed:dateCreated | 2002-4-17 | lld:pubmed |
| pubmed-article:11959568 | pubmed:abstractText | Posaconazole (SCH 56592) was tested against 25 strains of Coccidioides immitis to determine their in vitro susceptibilities. The geometric mean 48-h MIC of posaconazole (POSA) was 0.5 microg/ml, the MIC range was 0.25 to 1 microg/ml, and the MIC at which 50% of the isolates tested are inhibited (MIC50) and the MIC90 were 0.5 and 1 microg/ml, respectively. The geometric mean 48-h MIC of itraconazole (ITRA) was 0.23 microg/ml, the MIC range was 0.125 to 0.5 microg/ml, and the MIC50 and MIC90 were both 0.25 microg/ml. Two strains of C. immitis were selected for in vivo studies on the basis of the POSA 48-h MICs for the isolates. POSA orally administered at 0.01, 0.1, 0.5, 1, 5, and 10 mg/kg of body weight/day was compared with ITRA administered at 10 and 30 mg/kg three times a day. The spleens and livers of mice that died or survived to day 50 were removed to measure the fungal burdens. Mice had >or=90% survival when they were treated with >or=0.5 mg of POSA per kg or 30 mg of ITRA per kg. Cultures of whole spleens and livers from mice treated with 10 mg of POSA per kg showed >or=70% sterilization. No sterilization of whole spleens and livers from mice treated with ITRA was seen. POSA displayed potent in vivo activity against the two strains of C. immitis tested. | lld:pubmed |
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| pubmed-article:11959568 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11959568 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11959568 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11959568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11959568 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11959568 | pubmed:month | May | lld:pubmed |
| pubmed-article:11959568 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:11959568 | pubmed:author | pubmed-author:NajvarLaura... | lld:pubmed |
| pubmed-article:11959568 | pubmed:author | pubmed-author:GraybillJohn... | lld:pubmed |
| pubmed-article:11959568 | pubmed:author | pubmed-author:GonzálezGlori... | lld:pubmed |
| pubmed-article:11959568 | pubmed:author | pubmed-author:TijerinaRolan... | lld:pubmed |
| pubmed-article:11959568 | pubmed:author | pubmed-author:BocanegraRosi... | lld:pubmed |
| pubmed-article:11959568 | pubmed:author | pubmed-author:RinaldiMichae... | lld:pubmed |
| pubmed-article:11959568 | pubmed:author | pubmed-author:LoebenbergDav... | lld:pubmed |
| pubmed-article:11959568 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11959568 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:11959568 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11959568 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11959568 | pubmed:pagination | 1352-6 | lld:pubmed |
| pubmed-article:11959568 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11959568 | pubmed:meshHeading | pubmed-meshheading:11959568... | lld:pubmed |
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| pubmed-article:11959568 | pubmed:meshHeading | pubmed-meshheading:11959568... | lld:pubmed |
| pubmed-article:11959568 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11959568 | pubmed:articleTitle | In vitro and in vivo activities of posaconazole against Coccidioides immitis. | lld:pubmed |
| pubmed-article:11959568 | pubmed:affiliation | Department of Medicine, Division of Infectious Diseases (7881) , The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. gmglez@yahoo.com.mx | lld:pubmed |
| pubmed-article:11959568 | pubmed:publicationType | Journal Article | lld:pubmed |
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