| pubmed-article:11956231 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C0029453 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C1516819 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C0042382 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C1416917 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C2247140 | lld:lifeskim |
| pubmed-article:11956231 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:11956231 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11956231 | pubmed:dateCreated | 2002-4-16 | lld:pubmed |
| pubmed-article:11956231 | pubmed:abstractText | The low-density lipoprotein receptor-related protein (Lrp)-5 functions as a Wnt coreceptor. Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass phenotype. In vivo and in vitro analyses indicate that this phenotype becomes evident postnatally, and demonstrate that it is secondary to decreased osteoblast proliferation and function in a Cbfa1-independent manner. Lrp5 is expressed in osteoblasts and is required for optimal Wnt signaling in osteoblasts. In addition, Lrp5-deficient mice display persistent embryonic eye vascularization due to a failure of macrophage-induced endothelial cell apoptosis. These results implicate Wnt proteins in the postnatal control of vascular regression and bone formation, two functions affected in many diseases. Moreover, these features recapitulate human osteoporosis-pseudoglioma syndrome, caused by LRP5 inactivation. | lld:pubmed |
| pubmed-article:11956231 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11956231 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11956231 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11956231 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11956231 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:KarsentyGerar... | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:ChanLawrenceL | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:KatoMasakiM | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:PatelMillan... | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:LevasseurRegi... | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:LobovIvanI | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:ChangBenny... | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:GlassDonald... | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:HartmannChris... | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:LiLanL | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:HwangTae-HoTH | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:BraytonCory... | lld:pubmed |
| pubmed-article:11956231 | pubmed:author | pubmed-author:LangRichard... | lld:pubmed |
| pubmed-article:11956231 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11956231 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11956231 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:11956231 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11956231 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11956231 | pubmed:pagination | 303-14 | lld:pubmed |
| pubmed-article:11956231 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:11956231 | pubmed:meshHeading | pubmed-meshheading:11956231... | lld:pubmed |
| pubmed-article:11956231 | pubmed:meshHeading | pubmed-meshheading:11956231... | lld:pubmed |
| pubmed-article:11956231 | pubmed:meshHeading | pubmed-meshheading:11956231... | lld:pubmed |
| pubmed-article:11956231 | pubmed:meshHeading | pubmed-meshheading:11956231... | lld:pubmed |
| pubmed-article:11956231 | pubmed:meshHeading | pubmed-meshheading:11956231... | lld:pubmed |
| pubmed-article:11956231 | pubmed:meshHeading | pubmed-meshheading:11956231... | lld:pubmed |
