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pubmed-article:11953832pubmed:abstractTextRecent evidences suggest that malignant mesothelioma may be sensitive to immunotherapy; however, little is known about malignant mesothelioma-associated tumour antigens. Focusing on cancer/testis antigens, the expression of well-characterised immunogenic tumour-associated antigens was investigated in malignant mesothelioma cells. At variance with MAGE-4 and NY-ESO-1, malignant mesothelioma cells frequently expressed MAGE-1, -2 and -3, GAGE 1-2, GAGE 1-6, SSX-2 and SSX 1-5, and distinct malignant mesothelioma cells concomitantly expressed at least four cancer/testis antigens. Additionally, the tumour-associated antigens RAGE-1 was expressed at high levels in both benign and malignant mesothelial cells. Lastly, treatment with the DNA hypomethylating agent 5-aza-2'-deoxycytidine induced and up-regulated the expression of the cancer/testis antigen examined in malignant mesothelioma cells. Overall, these findings strongly suggest that cancer/testis antigens-based immunotherapy may represent a suitable therapeutic approach to malignant mesothelioma, and foresee the clinical use of 5-aza-2'-deoxycytidine to design new chemo-immunotherapeutic strategies in malignant mesothelioma patients.lld:pubmed
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pubmed-article:11953832pubmed:authorpubmed-author:MartiniFFlld:pubmed
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pubmed-article:11953832pubmed:copyrightInfoCopyright 2002 Cancer Research UKlld:pubmed
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pubmed-article:11953832pubmed:volume86lld:pubmed
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pubmed-article:11953832pubmed:pagination979-82lld:pubmed
pubmed-article:11953832pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:11953832pubmed:articleTitleCancer testis antigens expression in mesothelioma: role of DNA methylation and bioimmunotherapeutic implications.lld:pubmed
pubmed-article:11953832pubmed:affiliationCancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.lld:pubmed
pubmed-article:11953832pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11953832pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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