pubmed-article:11953832 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0025500 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0039597 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0376452 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:11953832 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:11953832 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:11953832 | pubmed:dateCreated | 2002-4-15 | lld:pubmed |
pubmed-article:11953832 | pubmed:abstractText | Recent evidences suggest that malignant mesothelioma may be sensitive to immunotherapy; however, little is known about malignant mesothelioma-associated tumour antigens. Focusing on cancer/testis antigens, the expression of well-characterised immunogenic tumour-associated antigens was investigated in malignant mesothelioma cells. At variance with MAGE-4 and NY-ESO-1, malignant mesothelioma cells frequently expressed MAGE-1, -2 and -3, GAGE 1-2, GAGE 1-6, SSX-2 and SSX 1-5, and distinct malignant mesothelioma cells concomitantly expressed at least four cancer/testis antigens. Additionally, the tumour-associated antigens RAGE-1 was expressed at high levels in both benign and malignant mesothelial cells. Lastly, treatment with the DNA hypomethylating agent 5-aza-2'-deoxycytidine induced and up-regulated the expression of the cancer/testis antigen examined in malignant mesothelioma cells. Overall, these findings strongly suggest that cancer/testis antigens-based immunotherapy may represent a suitable therapeutic approach to malignant mesothelioma, and foresee the clinical use of 5-aza-2'-deoxycytidine to design new chemo-immunotherapeutic strategies in malignant mesothelioma patients. | lld:pubmed |
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pubmed-article:11953832 | pubmed:language | eng | lld:pubmed |
pubmed-article:11953832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11953832 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:11953832 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11953832 | pubmed:month | Mar | lld:pubmed |
pubmed-article:11953832 | pubmed:issn | 0007-0920 | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:MartiniFF | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:TognonMM | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:GaudinoGG | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:MairJJ | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:MaraskovskyEE | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:AltomonteMM | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:ColizziFF | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:CebonJJ | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:LibenerRR | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:NataliLL | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:JungbluthAA | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:CoralSS | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:MuttiLL | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:SigalottiLL | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:VianaleGG | lld:pubmed |
pubmed-article:11953832 | pubmed:author | pubmed-author:CacciottiPP | lld:pubmed |
pubmed-article:11953832 | pubmed:copyrightInfo | Copyright 2002 Cancer Research UK | lld:pubmed |
pubmed-article:11953832 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11953832 | pubmed:day | 18 | lld:pubmed |
pubmed-article:11953832 | pubmed:volume | 86 | lld:pubmed |
pubmed-article:11953832 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11953832 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11953832 | pubmed:pagination | 979-82 | lld:pubmed |
pubmed-article:11953832 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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pubmed-article:11953832 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:11953832 | pubmed:articleTitle | Cancer testis antigens expression in mesothelioma: role of DNA methylation and bioimmunotherapeutic implications. | lld:pubmed |
pubmed-article:11953832 | pubmed:affiliation | Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy. | lld:pubmed |
pubmed-article:11953832 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11953832 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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