| pubmed-article:11953315 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C0028944 | lld:lifeskim |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C0245726 | lld:lifeskim |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C0032200 | lld:lifeskim |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:11953315 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:11953315 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11953315 | pubmed:dateCreated | 2002-4-15 | lld:pubmed |
| pubmed-article:11953315 | pubmed:abstractText | Central nervous system development requires precise and localized regulation of neural precursor behaviour. Here we show how the interaction between growth factor and integrin signalling pathways provides a mechanism for such precision in oligodendrocyte progenitor (OP) proliferation. While physiological concentrations of platelet-derived growth factor (PDGF) were not in themselves sufficient to promote OP proliferation, they did so on extracellular matrix (ECM) substrates that bind alpha(v)beta3 integrin. Upon PDGF-AA exposure and alpha(v)beta3 engagement, a physical co-association between both receptors was demonstrated, confirming the interaction between these signalling pathways. Furthermore, we found that PDGFalphaR stimulated a protein kinase C-dependent activation of integrin alpha(v)beta3, which in turn induced OP proliferation via a phosphatidylinositol 3-kinase-dependent signalling pathway. These studies establish a mechanism by which OP proliferation is dependent on the availability of both an ECM ligand and a mitogenic growth factor. Growth factor- mediated integrin activation is the critical integrative step in proliferation signalling, and ensures that the response of neural precursor cells to long-range cues can be regulated by their cellular neighbours, allowing precise control of cell behaviour during development. | lld:pubmed |
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| pubmed-article:11953315 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11953315 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11953315 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11953315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11953315 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11953315 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11953315 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:11953315 | pubmed:author | pubmed-author:BaderJ EJE | lld:pubmed |
| pubmed-article:11953315 | pubmed:author | pubmed-author:ShattilSanfor... | lld:pubmed |
| pubmed-article:11953315 | pubmed:author | pubmed-author:ffrench-Const... | lld:pubmed |
| pubmed-article:11953315 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11953315 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11953315 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11953315 | pubmed:owner | NLM | lld:pubmed |
