| pubmed-article:11949826 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11949826 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11949826 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11949826 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:11949826 | lifeskim:mentions | umls-concept:C0555198 | lld:lifeskim |
| pubmed-article:11949826 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11949826 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:11949826 | lifeskim:mentions | umls-concept:C0034537 | lld:lifeskim |
| pubmed-article:11949826 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11949826 | pubmed:dateCreated | 2002-4-12 | lld:pubmed |
| pubmed-article:11949826 | pubmed:abstractText | Radiotherapy is the standard treatment for glioblastoma. Here, we assessed the radiosensitivity of 12 human malignant glioma cell lines in vitro and correlated these data with irradiation-induced cell cycle changes, chemosensitivity profiles and BCL-2 family protein expression. Irradiation at 3 Gy failed to cause major cell cycle perturbations. Radioresistance was associated with collateral sensitivity to the topoisomerase II inhibitors, teniposide and doxorubicin. High levels of BCL-XL and low levels of BAX were independently linked to radioresistance. Ectopic expression of a BAX transgene induced radiosensitization in the LN-18 cell line. Thus, BCL-2 family protein expression modulates radiosensitivity in human glioma cells and targeted alterations in BCL-2 family protein expression are a promising strategy to improve the therapeutic efficacy of radiotherapy for gliomas. | lld:pubmed |
| pubmed-article:11949826 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11949826 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11949826 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11949826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11949826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11949826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11949826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11949826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11949826 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11949826 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11949826 | pubmed:issn | 0167-594X | lld:pubmed |
| pubmed-article:11949826 | pubmed:author | pubmed-author:WellerMichael... | lld:pubmed |
| pubmed-article:11949826 | pubmed:author | pubmed-author:StrefferJohan... | lld:pubmed |
| pubmed-article:11949826 | pubmed:author | pubmed-author:RimnerAndreas... | lld:pubmed |
| pubmed-article:11949826 | pubmed:author | pubmed-author:RiegerJohanne... | lld:pubmed |
| pubmed-article:11949826 | pubmed:author | pubmed-author:NaumannUlrike... | lld:pubmed |
| pubmed-article:11949826 | pubmed:author | pubmed-author:RodemannHans-... | lld:pubmed |
| pubmed-article:11949826 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11949826 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:11949826 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11949826 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11949826 | pubmed:pagination | 43-9 | lld:pubmed |
| pubmed-article:11949826 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:meshHeading | pubmed-meshheading:11949826... | lld:pubmed |
| pubmed-article:11949826 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11949826 | pubmed:articleTitle | BCL-2 family proteins modulate radiosensitivity in human malignant glioma cells. | lld:pubmed |
| pubmed-article:11949826 | pubmed:affiliation | Department of Neurology, University of Tübingen, Germany. | lld:pubmed |
| pubmed-article:11949826 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11949826 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11949826 | lld:pubmed |
