| pubmed-article:11937539 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C1512631 | lld:lifeskim |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:11937539 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11937539 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11937539 | pubmed:dateCreated | 2002-4-8 | lld:pubmed |
| pubmed-article:11937539 | pubmed:abstractText | One of the major unresolved questions in B cell biology is how the B cell Ag receptor (BCR) differentially signals to transduce anergy, apoptosis, proliferation, or differentiation during B cell maturation. We now report that extracellularly regulated kinase-mitogen-activated protein kinase (Erk-MAP kinase) can play dual roles in the regulation of the cell fate of the immature B cell lymphoma, WEHI-231, depending on the kinetics and context of Erk-MAP kinase activation. First, we show that the BCR couples to an early (< or =2 h) Erk-MAP kinase signal which activates a phospholipase A(2) pathway that we have previously shown to mediate collapse of mitochondrial membrane potential, resulting in depletion of cellular ATP and cathepsin B execution of apoptosis. Rescue of BCR-driven apoptosis by CD40 signaling desensitizes such early extracellularly regulated kinase (Erk) signaling and hence uncouples the BCR from the apoptotic mitochondrial phospholipase A(2) pathway. A second role for Erk-MAP kinase in promoting the growth and proliferation of WEHI-231 immature B cells is evidenced by data showing that proliferating and CD40-stimulated WEHI-231 B cells exhibit a sustained cycling pattern (8-48 h) of Erk activation that correlates with cell growth and proliferation. This growth-promoting role for Erk signaling is supported by three key pieces of evidence: 1) signaling via the BCR, under conditions that induce growth arrest, completely abrogates sustained Erk activation; 2) CD40-mediated rescue from growth arrest correlates with restoration of cycling Erk activation; and 3) sustained inhibition of Erk prevents CD40-mediated rescue of BCR-driven growth arrest of WEHI-231 immature B cells. Erk-MAP kinase can therefore induce diverse biological responses in WEHI-231 cells depending on the context and kinetics of activation. | lld:pubmed |
| pubmed-article:11937539 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11937539 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11937539 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11937539 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11937539 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11937539 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11937539 | pubmed:author | pubmed-author:GauldStephen... | lld:pubmed |
| pubmed-article:11937539 | pubmed:author | pubmed-author:BlairDerekD | lld:pubmed |
| pubmed-article:11937539 | pubmed:author | pubmed-author:MossCatriona... | lld:pubmed |
| pubmed-article:11937539 | pubmed:author | pubmed-author:ReidSteven... | lld:pubmed |
| pubmed-article:11937539 | pubmed:author | pubmed-author:HarnettMargar... | lld:pubmed |
| pubmed-article:11937539 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11937539 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11937539 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:11937539 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11937539 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11937539 | pubmed:pagination | 3855-64 | lld:pubmed |
| pubmed-article:11937539 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11937539 | pubmed:meshHeading | pubmed-meshheading:11937539... | lld:pubmed |
| pubmed-article:11937539 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11937539 | pubmed:articleTitle | Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells. | lld:pubmed |
| pubmed-article:11937539 | pubmed:affiliation | Department of Immunology and Bacteriology, University of Glasgow, Glasgow, United Kingdom. | lld:pubmed |
| pubmed-article:11937539 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11937539 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:26413 | entrezgene:pubmed | pubmed-article:11937539 | lld:entrezgene |
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