| pubmed-article:11936566 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11936566 | lifeskim:mentions | umls-concept:C0753474 | lld:lifeskim |
| pubmed-article:11936566 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:11936566 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11936566 | pubmed:dateCreated | 2002-4-8 | lld:pubmed |
| pubmed-article:11936566 | pubmed:abstractText | The pharmacokinetics of valspodar (PSC 833), a selective second-generation P-glycoprotein modulator, was evaluated as part of a Phase I study to modulate paclitaxel therapy in 15 patients with refractory malignancies. Valspodar was given intravenously at 1.42 mg/kg/h for 2 hours, followed by a 27-hour continuous infusion at 0.42 mg/kg/h. Serial blood samples were obtained after intravenous infusion of valspodar and paclitaxel. Valspodar disposition was best described by a linear two-compartment model. The median (range) valspodar clearance was 0.40 ml/min/kg (0.07-1.40 ml/min/kg). The 20-fold interpatient variability in valspodar clearance was not correlated with age, body weight, orgender but might be associated with coadministered medications that were metabolized via cytochrome P450 3A-mediated elimination. Valspodar whole-blood concentrations were maintained above the target threshold of 1000 ng/ml for a median of 32 hours. The pharmacokinetic model generated from this study allows for application in future studies to optimize the use of valspodar. | lld:pubmed |
| pubmed-article:11936566 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11936566 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11936566 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11936566 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11936566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11936566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11936566 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11936566 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11936566 | pubmed:issn | 0091-2700 | lld:pubmed |
| pubmed-article:11936566 | pubmed:author | pubmed-author:McLeodHoward... | lld:pubmed |
| pubmed-article:11936566 | pubmed:author | pubmed-author:MaMargaret... | lld:pubmed |
| pubmed-article:11936566 | pubmed:author | pubmed-author:WesterveltPet... | lld:pubmed |
| pubmed-article:11936566 | pubmed:author | pubmed-author:FracassoPaula... | lld:pubmed |
| pubmed-article:11936566 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11936566 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:11936566 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11936566 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11936566 | pubmed:pagination | 412-8 | lld:pubmed |
| pubmed-article:11936566 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:meshHeading | pubmed-meshheading:11936566... | lld:pubmed |
| pubmed-article:11936566 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11936566 | pubmed:articleTitle | Pharmacokinetic study of infusional valspodar. | lld:pubmed |
| pubmed-article:11936566 | pubmed:affiliation | Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. | lld:pubmed |
| pubmed-article:11936566 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11936566 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11936566 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11936566 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
