| pubmed-article:11931633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C0376604 | lld:lifeskim |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C0063592 | lld:lifeskim |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:11931633 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:11931633 | pubmed:issue | Pt 2 | lld:pubmed |
| pubmed-article:11931633 | pubmed:dateCreated | 2002-7-3 | lld:pubmed |
| pubmed-article:11931633 | pubmed:abstractText | Ca(2+) uptake by mitochondria is a potentially important buffering system able to control cytosolic [Ca(2+)]. In chromaffin cells, we have shown previously that stimulation of either Ca(2+) entry or Ca(2+) release via ryanodine receptors triggers large increases in mitochondrial [Ca(2+)] ([Ca(2+)](M)) approaching the millimolar range, whose blockade dramatically enhances catecholamine secretion [Montero, Alonso, Carnicero, Cuchillo-Ibañez, Albillos, Garcia, Carcia-Sancho and Alvarez (2000) Nat. Cell Biol. 2, 57-61]. In the present study, we have studied the effect of stimulation of inositol 1,4,5-trisphosphate (InsP(3)) receptors using histamine. We find that histamine produces a heterogeneous increase in [Ca(2+)](M), reaching peak levels at approx. 1 microM in 70% of the mitochondrial space to several hundred micromolar in 2-3% of mitochondria. Intermediate levels were found in the rest of the mitochondrial space. Single-cell imaging experiments with aequorin showed that the heterogeneity had both an intercellular and a subcellular origin. Those mitochondria responding to histamine with increases in [Ca(2+)](M) much greater than 1 microM (30%) were the same as those that also responded with large increases in [Ca(2+)](M) following stimulation with either high-K(+) medium or caffeine. Blocking mitochondrial Ca(2+) uptake with protonophores or mitochondrial inhibitors also enhanced catecholamine secretion induced by histamine. These results suggest that some InsP(3) receptors tightly co-localize with ryanodine receptors and voltage-dependent Ca(2+) channels in defined subplasmalemmal functional units designed to control secretion induced by different stimuli. | lld:pubmed |
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| pubmed-article:11931633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11931633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11931633 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11931633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11931633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11931633 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11931633 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:11931633 | pubmed:author | pubmed-author:AlvarezJavier... | lld:pubmed |
| pubmed-article:11931633 | pubmed:author | pubmed-author:VillalobosCar... | lld:pubmed |
| pubmed-article:11931633 | pubmed:author | pubmed-author:MonteroMayteM | lld:pubmed |
| pubmed-article:11931633 | pubmed:author | pubmed-author:AlonsoMaria... | lld:pubmed |
| pubmed-article:11931633 | pubmed:author | pubmed-author:Cuchillo-Ibáñ... | lld:pubmed |
| pubmed-article:11931633 | pubmed:author | pubmed-author:OlivaresRomán... | lld:pubmed |
| pubmed-article:11931633 | pubmed:author | pubmed-author:AlbillosAlmud... | lld:pubmed |
| pubmed-article:11931633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11931633 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11931633 | pubmed:volume | 365 | lld:pubmed |
| pubmed-article:11931633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11931633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11931633 | pubmed:pagination | 451-9 | lld:pubmed |
| pubmed-article:11931633 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:meshHeading | pubmed-meshheading:11931633... | lld:pubmed |
| pubmed-article:11931633 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11931633 | pubmed:articleTitle | Effect of inositol 1,4,5-trisphosphate receptor stimulation on mitochondrial [Ca2+] and secretion in chromaffin cells. | lld:pubmed |
| pubmed-article:11931633 | pubmed:affiliation | Departamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), Spain. | lld:pubmed |
| pubmed-article:11931633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11931633 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
