| pubmed-article:11931623 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11931623 | lifeskim:mentions | umls-concept:C0033262 | lld:lifeskim |
| pubmed-article:11931623 | lifeskim:mentions | umls-concept:C0024337 | lld:lifeskim |
| pubmed-article:11931623 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11931623 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:11931623 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11931623 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11931623 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:11931623 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11931623 | pubmed:dateCreated | 2002-4-4 | lld:pubmed |
| pubmed-article:11931623 | pubmed:abstractText | The 5-tetrazole amide of L-N(6)-(1-iminoethyl)lysine (L-NIL), L-N(6)-(1-iminoethyl)lysine 5-tetrazole amide (1), has been prepared and evaluated. In contrast to L-NIL, 1 is a stable, nonhygroscopic, crystalline solid. Unlike L-NIL, 1 has minimal inhibitory activity in vitro on human inducible nitric oxide synthase (iNOS). However, it is rapidly converted in vivo to L-NIL and produces dose-dependent inhibition of iNOS in acute and chronic models of inflammation in the rodent with efficacy comparable to L-NIL. In addition, both 1 and L-NIL exhibit significant and comparable in vivo selectivity for the inhibition of iNOS vs endothelial NOS. Doses approximately 80-fold greater than those that inhibited inflammation do not elevate systemic blood pressure. In summary, both the physical properties and the pharmacological profile of 1 make it an ideal molecule for preclinical and clinical studies on the role of selective iNOS inhibitors in mediating inflammatory disease processes. | lld:pubmed |
| pubmed-article:11931623 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11931623 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11931623 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11931623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11931623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11931623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11931623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11931623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11931623 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11931623 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11931623 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:ManningPamela... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:ConnorJane... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:ZhangYanY | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:HallinanE... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:TsymbalovSofy... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:DornClifford... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:PitzeleBarnet... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:HansenDonald... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:MooreWilliam... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:JeromeGina... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:BransonLinda... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:WidomskiDebor... | lld:pubmed |
| pubmed-article:11931623 | pubmed:author | pubmed-author:CurrieMark... | lld:pubmed |
| pubmed-article:11931623 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11931623 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:11931623 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:11931623 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11931623 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11931623 | pubmed:pagination | 1686-9 | lld:pubmed |
| pubmed-article:11931623 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
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| pubmed-article:11931623 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11931623 | pubmed:articleTitle | Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. | lld:pubmed |
| pubmed-article:11931623 | pubmed:affiliation | Department of Arthritis and Inflammation Pharmacology, Pharmacia Corporation, 4901 Searle Parkway, Skokie, Illinois 60077, USA. ann.hallinan@pharmacia.com | lld:pubmed |
| pubmed-article:11931623 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:11931623 | lld:chembl |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11931623 | lld:pubmed |
