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pubmed-article:11930227pubmed:dateCreated2002-4-3lld:pubmed
pubmed-article:11930227pubmed:abstractTextThe purpose of the present study was to investigate the role of central arginine vasopressin (AVP) in corticotropin releasing hormone (CRH) induced fever in the rat. Guide cannulae were inserted into the third ventricle and placed over the ventral septal area (VSA). The content of arginine vasopressin in the VSA of the brain was determined by radioimmunoassay. Colon temperature was monitored in lightly restrained rats by insertion of a catheter mounted thermistor probe 5 cm in the rectum. The results demonstrated that intracerebroventricular (icv) injection of CRH increased AVP level in the VSA and the colonic temperature of the rats. Microinjection of AVP V(1) antagonist into the VSA 10 min before CRH administration significantly enhanced CRH-induced febrile response, while AVP V(1) antagonist itself did not have a significant effect on the colonic temperature. Furthermore, injection of AVP into the VSA 5 min before CRH administration (icv) suppressed the fever evoked by CRH. These findings suggest that CRH is an important factor that stimulates the release of AVP in the VSA during fever, and endogenous AVP in the VSA has an antipyretic action on the CRH-induced fever.lld:pubmed
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pubmed-article:11930227pubmed:authorpubmed-author:BaHHlld:pubmed
pubmed-article:11930227pubmed:authorpubmed-author:WangY PYPlld:pubmed
pubmed-article:11930227pubmed:authorpubmed-author:LiC JCJlld:pubmed
pubmed-article:11930227pubmed:authorpubmed-author:LuD XDXlld:pubmed
pubmed-article:11930227pubmed:authorpubmed-author:HuC FCFlld:pubmed
pubmed-article:11930227pubmed:authorpubmed-author:WangH DHDlld:pubmed
pubmed-article:11930227pubmed:authorpubmed-author:LüR JRJlld:pubmed
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pubmed-article:11930227pubmed:volume53lld:pubmed
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pubmed-article:11930227pubmed:pagination465-8lld:pubmed
pubmed-article:11930227pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11930227pubmed:year2001lld:pubmed
pubmed-article:11930227pubmed:articleTitleThe role of central arginine vasopressin in corticotropin releasing hormone-induced fever in rats.lld:pubmed
pubmed-article:11930227pubmed:affiliationDepartments of Pathophysiology, Medical College of Jinan University, Guangzhou 510632, China. obszb@jnu.edu.cnlld:pubmed
pubmed-article:11930227pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11930227pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed