| pubmed-article:11927553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11927553 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11927553 | lifeskim:mentions | umls-concept:C0600449 | lld:lifeskim |
| pubmed-article:11927553 | lifeskim:mentions | umls-concept:C1425073 | lld:lifeskim |
| pubmed-article:11927553 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:11927553 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11927553 | pubmed:dateCreated | 2002-4-2 | lld:pubmed |
| pubmed-article:11927553 | pubmed:abstractText | Thioredoxin-2 (Trx-2) is a mitochondria-specific member of the thioredoxin superfamily. Mitochondria have a crucial role in the signal transduction for apoptosis. To investigate the biological significance of Trx-2, we cloned chicken TRX-2 cDNA and generated clones of the conditional Trx-2-deficient cells using chicken B-cell line, DT40. Here we show that TRX-2 is an essential gene and that Trx-2-deficient cells undergo apoptosis upon repression of the TRX-2 transgene, showing an accumulation of intracellular reactive oxygen species (ROS). Cytochrome c is released from mitochondria, while caspase-9 and caspase-3, but not caspase-8, are activated upon inhibition of the TRX-2 transgene. In addition, Trx-2 and cytochrome c are co-immunoprecipitated in an in vitro assay. These results suggest that mitochondrial Trx-2 is essential for cell viability, playing a crucial role in the scavenging ROS in mitochondria and regulating the mitochondrial apoptosis signaling pathway. | lld:pubmed |
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| pubmed-article:11927553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11927553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11927553 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11927553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11927553 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11927553 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:UedaShugoS | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:YodoiJunjiJ | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:MasutaniHiros... | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:TanakaToruT | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:NishiyamaAkir... | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:WadaHiromiH | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:TakedaShunich... | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:NakamuraHajim... | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:Yamaguchi-Iwa... | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:HosoiFumihito... | lld:pubmed |
| pubmed-article:11927553 | pubmed:author | pubmed-author:SpyrouGiannis... | lld:pubmed |
| pubmed-article:11927553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11927553 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:11927553 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11927553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11927553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11927553 | pubmed:pagination | 1695-703 | lld:pubmed |
| pubmed-article:11927553 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11927553 | pubmed:meshHeading | pubmed-meshheading:11927553... | lld:pubmed |
| pubmed-article:11927553 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11927553 | pubmed:articleTitle | Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. | lld:pubmed |
| pubmed-article:11927553 | pubmed:affiliation | Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. | lld:pubmed |
| pubmed-article:11927553 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11927553 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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