| pubmed-article:11926380 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11926380 | lifeskim:mentions | umls-concept:C0178693 | lld:lifeskim |
| pubmed-article:11926380 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:11926380 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:11926380 | lifeskim:mentions | umls-concept:C0556643 | lld:lifeskim |
| pubmed-article:11926380 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11926380 | pubmed:dateCreated | 2002-4-2 | lld:pubmed |
| pubmed-article:11926380 | pubmed:abstractText | The biodistribution of radioactivity after the administration of a new tracer for alpha4beta2 nicotinic acetylcholine receptors (nAChRs), [123I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine (5-I-A-85380), was studied in ten healthy human subjects. Following administration of 98+/-6 MBq [123I]5-I-A-85380, serial whole-body images were acquired over 24 h and corrected for attenuation. One to four brain single-photon emission tomography (SPET) images were also acquired between 2.5 and 24 h. Estimates of radiation absorbed dose were calculated using MIRDOSE 3.1 with a dynamic bladder model and a dynamic gastrointestinal tract model. The estimates of the highest absorbed dose (microGy/MBq) were for the urinary bladder wall (71 and 140), lower large intestine wall (70 and 72), and upper large intestine wall (63 and 64), with 2.4-h and 4.8-h urine voiding intervals, respectively. The whole brain activity at the time of the initial whole-body imaging at 14 min was 5.0% of the injected dose. Consistent with the known distribution of alpha4beta2 nAChRs, SPET images showed the highest activity in the thalamus. These results suggest that [123I]5-I-A-85380 is a promising SPET agent to image alpha4beta2 nAChRs in humans, with acceptable dosimetry and high brain uptake. | lld:pubmed |
| pubmed-article:11926380 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11926380 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11926380 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11926380 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11926380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11926380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11926380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11926380 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11926380 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11926380 | pubmed:issn | 1619-7070 | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:FujitaMasahir... | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:SeibylJohn... | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:ZoghbiSami... | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:BaldwinRonald... | lld:pubmed |
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| pubmed-article:11926380 | pubmed:author | pubmed-author:EarlyMicheleM | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:HortiAndrew... | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:KoreNAndrei... | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:MukhinAlexey... | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:KhanShaukatS | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:BozkurtAliA | lld:pubmed |
| pubmed-article:11926380 | pubmed:author | pubmed-author:KimesAlane... | lld:pubmed |
| pubmed-article:11926380 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11926380 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:11926380 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11926380 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11926380 | pubmed:pagination | 183-90 | lld:pubmed |
| pubmed-article:11926380 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11926380 | pubmed:meshHeading | pubmed-meshheading:11926380... | lld:pubmed |
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| pubmed-article:11926380 | pubmed:meshHeading | pubmed-meshheading:11926380... | lld:pubmed |
| pubmed-article:11926380 | pubmed:meshHeading | pubmed-meshheading:11926380... | lld:pubmed |
| pubmed-article:11926380 | pubmed:meshHeading | pubmed-meshheading:11926380... | lld:pubmed |
| pubmed-article:11926380 | pubmed:meshHeading | pubmed-meshheading:11926380... | lld:pubmed |
| pubmed-article:11926380 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11926380 | pubmed:articleTitle | Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects. | lld:pubmed |
| pubmed-article:11926380 | pubmed:affiliation | Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut/116A2, West Haven 06516, USA. masahiro.fujita@yale.edu | lld:pubmed |
| pubmed-article:11926380 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11926380 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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